{"id":"4f43a2c3-6ee5-584d-a71b-42cf6cf63fb5","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-zinc-shp1","predicate":"reduced","statement":"Increased zinc influx reduced recruitment of SHP-1 to the T-cell receptor activation complex.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6f96ab0a-52c5-57d1-bdf2-da1f333c620f","mechanism_event_label":"The zinc signal reduced recruitment of an inhibitory phosphatase.","subject":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"object":{"id":"2288d834-48da-5698-918a-6d865833bf94","slug":"shp1-tcr-recruitment","display_name":"SHP-1 recruitment to the T-cell receptor complex","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f96ab0a-52c5-57d1-bdf2-da1f333c620f","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-zinc-shp1-event","event_type":"biochemical_relationship","label":"The zinc signal reduced recruitment of an inhibitory phosphatase.","description":"Increased zinc influx reduced recruitment of SHP-1 to the T-cell receptor activation complex.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"46507725-2963-5d81-a8a5-8f8a524ce0c4","slug":"ptpn6","display_name":"Human SHP-1 / PTPN6","entity_type_key":"protein"},"role":"affected_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"517e6e15-f4f2-579f-b4e8-b5a5a40345f1","slug":"slc39a6","display_name":"Human zinc transporter ZIP6 / SLC39A6","entity_type_key":"protein"},"role":"upstream_transporter","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2288d834-48da-5698-918a-6d865833bf94","slug":"shp1-tcr-recruitment","display_name":"SHP-1 recruitment to the T-cell receptor complex","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Human SHP-1 / PTPN6 (affected_protein); Human zinc transporter ZIP6 / SLC39A6 (upstream_transporter)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-signaling-sources/21422171-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"e3b0e519eb5c44185655c0195cb81c713f2b005d70a982466e3e041e997fae59\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human T-cell receptor signaling study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Receptor activation, extracellular zinc availability and ZIP6 suppression comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Culture zinc availability and local signals cannot be mapped directly to oral doses or plasma thresholds. Calcium fluorescence tracks the signal rather than proving one specific calcium channel mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The zinc signal reduced recruitment of an inhibitory phosphatase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-sig-21422171] Regulation of T cell receptor signaling by activation-induced zinc influx. (2011). https://pubmed.ncbi.nlm.nih.gov/21422171/ DOI: 10.1084/jem.20100031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"CD4 T cells at the receptor-contact region","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34ca62d7-21d9-5c7e-9c19-d24e5343bead","evidence_kind":"source_excerpt","locator":"Lines 1027-1039","start_line":1027,"end_line":1039,"excerpt":"### zn-sig-zinc-shp1\nIncreased zinc influx reduced recruitment of SHP-1 to the T-cell receptor activation complex.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The zinc signal reduced recruitment of an inhibitory phosphatase.\norganism: Homo sapiens\ntissue_or_cell_type: CD4 T cells at the receptor-contact region\nexperimental_model: Primary human T-cell receptor signaling study\nlimitations: Culture zinc availability and local signals cannot be mapped directly to oral doses or plasma thresholds. Calcium fluorescence tracks the signal rather than proving one specific calcium channel mechanism.\nexposure: Receptor activation, extracellular zinc availability and ZIP6 suppression comparisons.\ncross_nutrient: Human SHP-1 / PTPN6 (affected_protein); Human zinc transporter ZIP6 / SLC39A6 (upstream_transporter)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/21422171-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"e3b0e519eb5c44185655c0195cb81c713f2b005d70a982466e3e041e997fae59\"}\n[zn-sig-21422171] Regulation of T cell receptor signaling by activation-induced zinc influx. (2011). https://pubmed.ncbi.nlm.nih.gov/21422171/ DOI: 10.1084/jem.20100031","model_system":"Primary human T-cell receptor signaling study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-sig-21422171] Regulation of T cell receptor signaling by activation-induced zinc influx. (2011). https://pubmed.ncbi.nlm.nih.gov/21422171/ DOI: 10.1084/jem.20100031","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}