{"id":"4f31a03b-0e56-5ebd-9869-d62dca3263a4","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-load-vascular","predicate":"reduces_after_load","statement":"The methionine-loading visit showed reduced flow-mediated dilation alongside higher homocysteine; the time courses were similar in a smaller follow-up group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9334bc8a-d239-536b-b028-16535ca9806e","mechanism_event_label":"The loading experiment also measured a vascular response.","subject":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"object":{"id":"d5e874ad-b9c6-517a-b3db-0d0cbd84cec8","slug":"human-methionine-load-flow-dilation","display_name":"Flow-mediated brachial dilation after methionine loading","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9334bc8a-d239-536b-b028-16535ca9806e","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-load-vascular-event","event_type":"observed_relationship","label":"The loading experiment also measured a vascular response.","description":"The methionine-loading visit showed reduced flow-mediated dilation alongside higher homocysteine; 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unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy adults; 0.1 g/kg oral load and brachial-artery measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not isolate homocysteine as the sole mediator or demonstrate long-term cardiovascular events.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The loading experiment also measured a vascular response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9799203/ · DOI 10.1161/01.cir.98.18.1848","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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