{"id":"4eecf4fb-2f86-5508-b634-fb5afe67b7a1","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-rat-melatonin","predicate":"reduces","statement":"Myricetin treatment lowered nocturnal serum melatonin in rats.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dd241f45-ef79-5155-9c56-5fa23e573a16","mechanism_event_label":"A biochemical pathway change was accompanied by a hormone measurement.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"5f5bad58-01cf-5762-b911-69244ca4cbd3","slug":"rat-nocturnal-serum-melatonin","display_name":"Rat nocturnal serum melatonin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd241f45-ef79-5155-9c56-5fa23e573a16","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-rat-melatonin-event","event_type":"observed_relationship","label":"A biochemical pathway change was accompanied by a hormone measurement.","description":"Myricetin treatment lowered nocturnal serum melatonin in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5f5bad58-01cf-5762-b911-69244ca4cbd3","slug":"rat-nocturnal-serum-melatonin","display_name":"Rat nocturnal serum melatonin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat circadian experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No established human sleep effect or melatonin supplement interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A biochemical pathway change was accompanied by a hormone measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24076393/ · DOI 10.1016/j.bbrc.2013.09.076","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3dd3c236-5094-5bd8-a428-97f63696f50d","evidence_kind":"source_excerpt","locator":"Lines 572-578","start_line":572,"end_line":578,"excerpt":"## myricetin-rat-melatonin\nA biochemical pathway change was accompanied by a hormone measurement.\nMyricetin treatment lowered nocturnal serum melatonin in rats.\nModel: Rat circadian experiment.\nLimitations: No established human sleep effect or melatonin supplement interaction.\nEvidence access: Primary abstract\nThe flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24076393/ · DOI 10.1016/j.bbrc.2013.09.076","model_system":"Rat circadian experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}