{"id":"4e91dbe5-1361-53b4-b8a1-b1a3ec9f972c","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-mouse-egg-entry","predicate":"mediates_entry","statement":"TRPV3 mediated strontium influx into mouse eggs in the reported channel and activation experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2ff3da73-891d-5ab9-9bea-2cfb63e4212e","mechanism_event_label":"A calcium-permeable channel can also admit strontium in mouse eggs.","subject":{"id":"733f3820-01cf-5f49-9d54-f784d20e2697","slug":"mouse-trpv3","display_name":"Mouse TRPV3","entity_type_key":"protein"},"object":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"2ff3da73-891d-5ab9-9bea-2cfb63e4212e","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-mouse-egg-entry-event","event_type":"observed_relationship","label":"A calcium-permeable channel can also admit strontium in mouse eggs.","description":"TRPV3 mediated strontium influx into mouse eggs in the reported channel and activation experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"733f3820-01cf-5f49-9d54-f784d20e2697","slug":"mouse-trpv3","display_name":"Mouse TRPV3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse egg electrophysiology and genetic experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Laboratory artificial activation; no claim about dietary strontium or human fertility.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A calcium-permeable channel can also admit strontium in mouse eggs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TRPV3 channels mediate strontium-induced mouse-egg activation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24316078/ · DOI 10.1016/j.celrep.2013.11.007","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9931e22c-b106-523b-bec7-016c76b2b837","evidence_kind":"source_excerpt","locator":"Lines 382-388","start_line":382,"end_line":388,"excerpt":"## strontium-mouse-egg-entry\nA calcium-permeable channel can also admit strontium in mouse eggs.\nTRPV3 mediated strontium influx into mouse eggs in the reported channel and activation experiments.\nModel: Mouse egg electrophysiology and genetic experiments.\nLimitations: Laboratory artificial activation; no claim about dietary strontium or human fertility.\nEvidence access: Primary full text\nTRPV3 channels mediate strontium-induced mouse-egg activation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24316078/ · DOI 10.1016/j.celrep.2013.11.007","model_system":"Mouse egg electrophysiology and genetic experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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