{"id":"4e9126da-48bb-5367-8472-e91c26164231","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-gsh-context","predicate":"reduces","statement":"In the glutathione-containing copper system, resveratrol reduced radical formation and glutathione-disulfide formation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"736c5da8-7595-5815-a99c-357f4ca9dcc0","mechanism_event_label":"Glutathione changes the redox reaction rather than merely adding another antioxidant label.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"68acdd1b-e1ee-5385-8e79-b7dfe63deb4f","slug":"resveratrol-copper-gsh-radicals","display_name":"Hydroxyl-radical generation in copper/glutathione assays","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"736c5da8-7595-5815-a99c-357f4ca9dcc0","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-gsh-context-event","event_type":"observed_relationship","label":"Glutathione changes the redox reaction rather than merely adding another antioxidant label.","description":"In the glutathione-containing copper system, resveratrol reduced radical formation and glutathione-disulfide formation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"68acdd1b-e1ee-5385-8e79-b7dfe63deb4f","slug":"resveratrol-copper-gsh-radicals","display_name":"Hydroxyl-radical generation in copper/glutathione assays","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Chemical assay with glutathione versus ascorbate conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a measurement of GSH synthesis, recycling or depletion in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Glutathione changes the redox reaction rather than merely adding another antioxidant label.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11032413/ · DOI 10.1006/abbi.2000.1973","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6f3f3d98-8312-5541-8c27-d4d4d13eb9dd","evidence_kind":"source_excerpt","locator":"Lines 382-388","start_line":382,"end_line":388,"excerpt":"## resveratrol-gsh-context\nGlutathione changes the redox reaction rather than merely adding another antioxidant label.\nIn the glutathione-containing copper system, resveratrol reduced radical formation and glutathione-disulfide formation.\nModel: Chemical assay with glutathione versus ascorbate conditions.\nLimitations: Not a measurement of GSH synthesis, recycling or depletion in humans.\nEvidence access: Primary abstract\nEffects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11032413/ · DOI 10.1006/abbi.2000.1973","model_system":"Chemical assay with glutathione versus ascorbate conditions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}