{"id":"4e713bc3-f97f-506f-8599-dda5301dfcab","stable_key":"research:selenov-binds-ogt","predicate":"binds","statement":"SELENOV physically associated with OGT in the reported interaction assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"neutral","is_public":true,"mechanism_event_id":"e1fb87fb-9584-533c-bb7b-9a282c60a496","mechanism_event_label":"SELENOV was found to interact with the sugar-transfer enzyme OGT.","subject":{"id":"916cbbc3-1543-564d-85a5-fd6b7c209bef","slug":"selenov","display_name":"SELENOV","entity_type_key":"protein"},"object":{"id":"e0d1556b-a4d5-51d7-bad7-ab7a0cfc9ddf","slug":"ogt","display_name":"OGT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"e1fb87fb-9584-533c-bb7b-9a282c60a496","stable_key":"research:selenov-binds-ogt","event_type":"binding","label":"SELENOV was found to interact with the sugar-transfer enzyme OGT.","description":"SELENOV physically associated with OGT in the reported interaction assays.","status":"active","compartment":null,"participants":[{"entity":{"id":"916cbbc3-1543-564d-85a5-fd6b7c209bef","slug":"selenov","display_name":"SELENOV","entity_type_key":"protein"},"role":"binding-partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e0d1556b-a4d5-51d7-bad7-ab7a0cfc9ddf","slug":"ogt","display_name":"OGT","entity_type_key":"protein"},"role":"binding-partner","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"HEK293T assay system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein-interaction experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding does not establish a catalytic substrate relationship.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mammalian proteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2252cfbe-f9f0-518e-9e25-6864c168cf18","evidence_kind":"curated_literature_summary","locator":"lines 810-820","start_line":810,"end_line":820,"excerpt":"## selenov-binds-ogt\n\nSELENOV was found to interact with the sugar-transfer enzyme OGT.\n\nSELENOV physically associated with OGT in the reported interaction assays.\n\nOrganism: mammalian proteins\nCell type: HEK293T assay system\nExperimental model: Protein-interaction experiments\nLimitations: Binding does not establish a catalytic substrate relationship.\nPrimary reference: [Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure](https://pubmed.ncbi.nlm.nih.gov/34167027/)","model_system":"Protein-interaction experiments","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"protein-glycosylation","plain_language":"SELENOV was found to interact with the sugar-transfer enzyme OGT.","evidence_scope":"direct_experimental","papers":[{"key":"chen-2021-selenov-ogt","title":"Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure","url":"https://pubmed.ncbi.nlm.nih.gov/34167027/","doi":"10.1016/j.redox.2021.102048","year":2021,"model":"Selenov-knockout mice and protein-interaction assays","summary":"Connects SELENOV with OGT binding and altered O-GlcNAcylation in adipose tissue."}]}}