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enzyme activities assessed in 40; before/after pharmacological-dose study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Probe indices are not proof of transcriptional induction or a quantified interaction with every substrate; no medication adjustment follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A human drug-metabolism interaction was measured with a specific probe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20716633/ · DOI 10.1158/1940-6207.CAPR-09-0155","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"061a2329-9bf3-5782-807c-ed555c19e2c7","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## resveratrol-human-cyp2d6\nA human drug-metabolism interaction was measured with a specific probe.\nAfter 1 g/day resveratrol for four weeks, the healthy-volunteer study found decreased CYP2D6 phenotypic activity using dextromethorphan as the probe.\nModel: 42 initiated; 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