{"id":"4db73958-50ac-514c-b71b-165f6e172492","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-folate-ferritin","predicate":"reduces","statement":"During the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b7afe717-72ac-52aa-a19f-366689a46971","mechanism_event_label":"During the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.","subject":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"object":{"id":"b36f4fd5-83df-5a4b-83c2-73fb25526b48","slug":"human-folate-and-ferritin-markers","display_name":"Human serum/RBC folate and ferritin markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b7afe717-72ac-52aa-a19f-366689a46971","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-folate-ferritin-event","event_type":"observed_relationship","label":"During the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.","description":"During the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b36f4fd5-83df-5a4b-83c2-73fb25526b48","slug":"human-folate-and-ferritin-markers","display_name":"Human serum/RBC folate and ferritin markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Purified hydroxytyrosol 45 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fourteen volunteers with mild hyperlipidemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A small baseline-comparison study cannot establish deficiency, iron depletion, or a causal nutrient interaction without controlled replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Fourteen volunteers with mild hyperlipidemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"During the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28063380/ DOI: 10.1016/j.redox.2016.12.014","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Nutrient and iron-status markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f14a94fb-2239-5159-97e6-5c2e4e23a43b","evidence_kind":"source_excerpt","locator":"Lines 110-119","start_line":110,"end_line":119,"excerpt":"## hydroxytyrosol-folate-ferritin\nDuring the same 45 mg/day trial, serum and red-cell folate and serum ferritin fell at weeks 4 and 8, while serum iron remained stable.\nModel/species: Fourteen volunteers with mild hyperlipidemia\nTissue/system: Nutrient and iron-status markers\nExposure: Purified hydroxytyrosol 45 mg/day\nRoute: Oral\nDuration: 8 weeks\nLimits: A small baseline-comparison study cannot establish deficiency, iron depletion, or a causal nutrient interaction without controlled replication.\nPrimary reference: Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28063380/ DOI: 10.1016/j.redox.2016.12.014\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Fourteen volunteers with mild hyperlipidemia","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}