{"id":"4db2935c-b400-5a60-9514-2c21fee6f160","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:hepatic-cyp1a2","predicate":"increases_in_recorded_experiment","statement":"Modafinil induced CYP1A2 in human hepatocyte cultures; the laboratory result does not establish a large caffeine exposure change in every user.","claim_class":"mechanistic","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f414091e-2006-5be7-abea-faaa47a9eb64","mechanism_event_label":"Modafinil induced CYP1A2 in human hepatocyte cultures; the laboratory result does not establish a large caffeine exposure change in every user.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"9b15c13c-a369-5d10-a76a-525e8b19221d","slug":"cyp1a2","display_name":"Human cytochrome P450 1A2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"f414091e-2006-5be7-abea-faaa47a9eb64","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:hepatic-cyp1a2-event","event_type":"biochemical_relationship","label":"Modafinil induced CYP1A2 in human hepatocyte cultures; the laboratory result does not establish a large caffeine exposure change in every user.","description":"In human liver preparations, modafinil competitively/reversibly inhibited CYP2C19 and induced CYP1A2, CYP2B6 and CYP3A activity in hepatocyte cultures. High-concentration CYP2C9 suppression was also reported. These laboratory findings must retain concentration and preparation rather than become universal clinical interaction rules. 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