{"id":"4d906627-59ad-5649-ab38-8a95d3813da5","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:plod2-telopeptide-hydroxylation","predicate":"hydroxylates","statement":"PLOD2/LH2 hydroxylates collagen telopeptide lysines, influencing the subsequent cross-link pathway.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d04bd46d-d30d-5fc5-a1d9-6d6a1b611162","mechanism_event_label":"This enzyme prepares lysines near collagen ends for particular cross-links.","subject":{"id":"e7ea826f-6609-5b8a-887c-0609970a06fe","slug":"plod2","display_name":"PLOD2","entity_type_key":"protein"},"object":{"id":"e5d1090a-c611-5bf4-8853-b20872be5589","slug":"collagen-telopeptide-lysine","display_name":"Collagen telopeptide lysine residues","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"d04bd46d-d30d-5fc5-a1d9-6d6a1b611162","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:plod2-telopeptide-hydroxylation-event","event_type":"biochemical_relationship","label":"This enzyme prepares lysines near collagen ends for particular cross-links.","description":"PLOD2/LH2 hydroxylates collagen telopeptide lysines, influencing the subsequent cross-link pathway.","status":"provisional","compartment":{"slug":"endoplasmic-reticulum","display_name":"Endoplasmic reticulum"},"participants":[{"entity":{"id":"e7ea826f-6609-5b8a-887c-0609970a06fe","slug":"plod2","display_name":"PLOD2","entity_type_key":"protein"},"role":"enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e5d1090a-c611-5bf4-8853-b20872be5589","slug":"collagen-telopeptide-lysine","display_name":"Collagen telopeptide lysine residues","entity_type_key":"protein_state"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6921f2ab-5efc-5e56-8ba1-39af114afbf8","slug":"collagen-telopeptide-hydroxylysine","display_name":"Collagen telopeptide hydroxylysine residues","entity_type_key":"protein_state"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human patient bone collagen biochemistry and PLOD2 variant analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This reaction modifies lysine already in a protein. It does not show that extra oral lysine increases the reaction or improves a clinical outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This enzyme prepares lysines near collagen ends for particular cross-links.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[plod2-bruck-2021] Abnormal Bone Collagen Cross-Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations (2021). https://pmc.ncbi.nlm.nih.gov/articles/PMC7990156/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Not specified as a whole tissue; see experimental model.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"117c006e-7de0-507e-b5ac-68fff5095e5e","evidence_kind":"source_excerpt","locator":"Lines 397-405","start_line":397,"end_line":405,"excerpt":"### plod2-telopeptide-hydroxylation\nPLOD2/LH2 hydroxylates collagen telopeptide lysines, influencing the subsequent cross-link pathway.\nPlain language: This enzyme prepares lysines near collagen ends for particular cross-links.\nCondition category: normal\norganism: Human\ntissue_or_cell_type: Not specified as a whole tissue; see experimental model.\nexperimental_model: Human patient bone collagen biochemistry and PLOD2 variant analysis.\nlimitations: This reaction modifies lysine already in a protein. It does not show that extra oral lysine increases the reaction or improves a clinical outcome.\n[plod2-bruck-2021] Abnormal Bone Collagen Cross-Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations (2021). https://pmc.ncbi.nlm.nih.gov/articles/PMC7990156/","model_system":"Human patient bone collagen biochemistry and PLOD2 variant analysis.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [plod2-bruck-2021] Abnormal Bone Collagen Cross-Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations (2021). https://pmc.ncbi.nlm.nih.gov/articles/PMC7990156/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}