{"id":"4d1b62b0-48f5-587e-928a-afac0d92391e","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-berberine-vascular-combination","predicate":"modifies_response_to","statement":"The rat study reported that berberine plus vanadyl acetylacetonate reduced hyperglycemia and improved vascular calcification, junction and barrier outcomes compared with single-agent conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d3b30abc-5636-57fb-a984-4bcd6307efb7","mechanism_event_label":"A specific tested combination is recorded rather than inferred from a shared pathway.","subject":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"object":{"id":"664d6382-87fc-577a-9a28-ae713035d2b1","slug":"vanadyl-acetylacetonate","display_name":"Bis(acetylacetonato)oxovanadium(IV)","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"d3b30abc-5636-57fb-a984-4bcd6307efb7","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-berberine-vascular-combination-event","event_type":"observed_relationship","label":"A specific tested combination is recorded rather than inferred from a shared pathway.","description":"The rat study reported that berberine plus vanadyl acetylacetonate reduced hyperglycemia and improved vascular calcification, junction and barrier outcomes compared with single-agent conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"664d6382-87fc-577a-9a28-ae713035d2b1","slug":"vanadyl-acetylacetonate","display_name":"Bis(acetylacetonato)oxovanadium(IV)","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Diabetic rats; primary abstract accessed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical formulation-specific findings; doses and formal synergy modeling are not resolved in accessed abstract. Not a recommendation to combine supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A specific tested combination is recorded rather than inferred from a shared pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Vanadyl Acetylacetonate and Berberine Synergistically Ameliorate Diabetes-induced Vascular Dysfunction and Reduce Endothelial Toxicity through ERK and Akt Regulation. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40775562/ · DOI 10.1007/s12011-025-04774-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dceed82a-ca5c-5408-b48b-d7ef49223ab8","evidence_kind":"source_excerpt","locator":"Lines 342-348","start_line":342,"end_line":348,"excerpt":"## vanadium-berberine-vascular-combination\nA specific tested combination is recorded rather than inferred from a shared pathway.\nThe rat study reported that berberine plus vanadyl acetylacetonate reduced hyperglycemia and improved vascular calcification, junction and barrier outcomes compared with single-agent conditions.\nModel: Diabetic rats; primary abstract accessed.\nLimitations: Preclinical formulation-specific findings; doses and formal synergy modeling are not resolved in accessed abstract. Not a recommendation to combine supplements.\nEvidence access: Primary abstract\nVanadyl Acetylacetonate and Berberine Synergistically Ameliorate Diabetes-induced Vascular Dysfunction and Reduce Endothelial Toxicity through ERK and Akt Regulation. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40775562/ · DOI 10.1007/s12011-025-04774-z","model_system":"Diabetic rats; primary abstract accessed.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"d36b30d972e756ca4d19b66f976980e206c65025bd4bbf4c127c17320bd019c2","revision_id":"70d42967-8032-5627-8670-f59841735e89","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}