{"id":"4d01f7f5-9c86-58fb-b33c-4c39b6a09a2b","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-cleaves-fibrinogen","predicate":"proteolyzes","statement":"Purified nattokinase proteolyzes human fibrinogen.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e18e0b9e-18a9-5dbb-a2d6-68e3100d39db","mechanism_event_label":"Purified nattokinase proteolyzes human fibrinogen.","subject":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"object":{"id":"3068e5f4-9564-5dfb-8333-f94e8b8d1af9","slug":"fibrinogen","display_name":"Human fibrinogen","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"e18e0b9e-18a9-5dbb-a2d6-68e3100d39db","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-cleaves-fibrinogen-event","event_type":"biochemical_relationship","label":"Purified nattokinase proteolyzes human fibrinogen.","description":"Purified fibrinogen","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3068e5f4-9564-5dfb-8333-f94e8b8d1af9","slug":"fibrinogen","display_name":"Human fibrinogen","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Bibliographic record and the EFSA opinion's account of this study reviewed. The primary article itself was not retrieved and is not indexed in PubMed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human protein substrates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Purified nattokinase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same access limitation as the fibrin record. The 1993 purification paper independently reports that the enzyme digests fibrin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human protein substrates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Purified nattokinase proteolyzes human fibrinogen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[fujita-fibrin-1995] Characterization of nattokinase-degraded products from human fibrinogen or cross-linked fibrin. (1995) Not indexed in PubMed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Purified fibrinogen","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"84ea5f73-e561-59b5-99f8-6c1e60b6592f","evidence_kind":"source_excerpt","locator":"Lines 114-114","start_line":114,"end_line":114,"excerpt":"Purified nattokinase proteolyzes human fibrinogen.","model_system":"Human protein substrates","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}