{"id":"4cfd4f7a-665c-5408-a61d-85d91a8b2d50","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:kbicarbonate-increases-urine-citrate","predicate":"changes","statement":"Potassium bicarbonate increased urine citrate excretion and clearance in the same comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d792f133-d990-5655-a71c-f178c135341c","mechanism_event_label":"An alkali salt without administered citrate reproduced the citraturic response.","subject":{"id":"5de32c9c-ee6a-506f-8e94-efd1698f434e","slug":"potassium-bicarbonate","display_name":"Potassium bicarbonate","entity_type_key":"chemical_species"},"object":{"id":"73f00d50-d3c9-5b8e-8e38-a5d004da46b7","slug":"urinary-citrate-excretion","display_name":"Urinary citrate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d792f133-d990-5655-a71c-f178c135341c","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:kbicarbonate-increases-urine-citrate-event","event_type":"biochemical_relationship","label":"An alkali salt without administered citrate reproduced the citraturic response.","description":"Potassium bicarbonate increased urine citrate excretion and clearance in the same comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5de32c9c-ee6a-506f-8e94-efd1698f434e","slug":"potassium-bicarbonate","display_name":"Potassium bicarbonate","entity_type_key":"chemical_species"},"role":"upstream","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"73f00d50-d3c9-5b8e-8e38-a5d004da46b7","slug":"urinary-citrate-excretion","display_name":"Urinary citrate excretion","entity_type_key":"cellular_process"},"role":"downstream","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"co-delivered-ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1c54abac-4dfd-5303-b0f4-37945245e18e","slug":"citrate","display_name":"Citrate","entity_type_key":"small_molecule"},"role":"urinary-anion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"edf44f6b-7b23-5b97-a86b-c940e5812b06","slug":"bicarbonate-ion","display_name":"Bicarbonate ion","entity_type_key":"ion"},"role":"alkali-context","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Potassium-salt anion determines effects on urinary citrate, which participates in calcium complexation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"Potassium bicarbonate increased urine citrate excretion and clearance in the same comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental-exposure","value_text":"Eight patients with stones, without potassium deficiency, compared after two weeks of potassium citrate, bicarbonate, or chloride at 80 mEq/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight patients with stones, without potassium deficiency, compared after two weeks of potassium citrate, bicarbonate, or chloride at 80 mEq/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight patients, short intervention; absence of potassium deficiency limits extrapolation to depletion. Alkali and citrate coeffects cannot be assigned to potassium cation alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An alkali salt without administered citrate reproduced the citraturic response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sakhaee-1991-salts] Contrasting effects of various potassium salts on renal citrate excretion (1991). https://pubmed.ncbi.nlm.nih.gov/1899422/ DOI: 10.1210/jcem-72-2-396","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"kidney and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7bcf321c-651e-5e78-8ae3-119d58cc919c","evidence_kind":"source_excerpt","locator":"Lines 1232-1244","start_line":1232,"end_line":1244,"excerpt":"### kbicarbonate-increases-urine-citrate\nPotassium bicarbonate increased urine citrate excretion and clearance in the same comparison.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An alkali salt without administered citrate reproduced the citraturic response.\norganism: Homo sapiens\ntissue_or_cell_type: kidney and urine\nexperimental_model: Eight patients with stones, without potassium deficiency, compared after two weeks of potassium citrate, bicarbonate, or chloride at 80 mEq/day.\nlimitations: Eight patients, short intervention; absence of potassium deficiency limits extrapolation to depletion. Alkali and citrate coeffects cannot be assigned to potassium cation alone.\ncross_nutrient: Potassium-salt anion determines effects on urinary citrate, which participates in calcium complexation.\nexperimental-exposure: Eight patients with stones, without potassium deficiency, compared after two weeks of potassium citrate, bicarbonate, or chloride at 80 mEq/day.\nendpoint: Potassium bicarbonate increased urine citrate excretion and clearance in the same comparison.\n[sakhaee-1991-salts] Contrasting effects of various potassium salts on renal citrate excretion (1991). https://pubmed.ncbi.nlm.nih.gov/1899422/ DOI: 10.1210/jcem-72-2-396","model_system":"Eight patients with stones, without potassium deficiency, compared after two weeks of potassium citrate, bicarbonate, or chloride at 80 mEq/day.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sakhaee-1991-salts] Contrasting effects of various potassium salts on renal citrate excretion (1991). https://pubmed.ncbi.nlm.nih.gov/1899422/ DOI: 10.1210/jcem-72-2-396","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}