{"id":"4c9a3ef9-c9c9-5871-a56f-e4cce3c1f4c3","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-long-cognition-null","predicate":"no_detected_change_in_recorded_comparison","statement":"The 323-person trial found no significant overall cognitive advantage at 96 weeks.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"263d8b7b-2561-5fe0-ad83-ddce19767459","mechanism_event_label":"The 323-person trial found no significant overall cognitive advantage at 96 weeks.","subject":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"object":{"id":"e42eed81-c5ea-5bd7-a16e-f4caaa0115d2","slug":"human-96week-cognition-ra","display_name":"Cognition in the 96-week RA-extract trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"263d8b7b-2561-5fe0-ad83-ddce19767459","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-long-cognition-null-event","event_type":"experimental_observation","label":"The 323-person trial found no significant overall cognitive advantage at 96 weeks.","description":"### ra-long-cognition-null\n\nThe 323-person trial found no significant overall cognitive advantage at 96 weeks.\nNonhypertensive subgroup wording requires verification: the abstract-listed changes do not align with its favorable conclusion.\nModel and exposure: Subjective or mild cognitive impairment; extract providing 500 mg RA/day; placebo-controlled, 24-week washout.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36502333/ | https://doi.org/10.3233/jad-220953 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"RA-rich lemon-balm extract","sequence_order":0,"notes":""},{"entity":{"id":"e42eed81-c5ea-5bd7-a16e-f4caaa0115d2","slug":"human-96week-cognition-ra","display_name":"Cognition in the 96-week RA-extract trial","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"extract constituent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"RA-rich lemon-balm extract\", \"comparator\": \"Placebo\", \"endpoint\": \"The 323-person trial found no significant overall cognitive advantage at 96 weeks.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Subjective or mild cognitive impairment; extract providing 500 mg RA/day; placebo-controlled, 24-week washout.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The 323-person trial found no significant overall cognitive advantage at 96 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. | https://pubmed.ncbi.nlm.nih.gov/36502333/ | https://doi.org/10.3233/jad-220953","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-long-cognition-null; Nonhypertensive subgroup wording requires verification: the abstract-listed changes do not align with its favorable conclusion.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5a6ee0bb-523c-5d87-988a-7fd4b90bc405","evidence_kind":"source_excerpt","locator":"Lines 473-479","start_line":473,"end_line":479,"excerpt":"### ra-long-cognition-null\n\nThe 323-person trial found no significant overall cognitive advantage at 96 weeks.\nNonhypertensive subgroup wording requires verification: the abstract-listed changes do not align with its favorable conclusion.\nModel and exposure: Subjective or mild cognitive impairment; extract providing 500 mg RA/day; placebo-controlled, 24-week washout.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36502333/ | https://doi.org/10.3233/jad-220953 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Subjective or mild cognitive impairment; extract providing 500 mg RA/day; placebo-controlled, 24-week washout.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}