{"id":"4c974116-2f0b-5797-8ce2-bf347b010be1","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-low-activates-camkii","predicate":"modulates","statement":"Rabbit hearts exposed to 2.7 mM K showed increased CaMKII activity; KN-93 prevented low-K early afterdepolarizations and ventricular arrhythmia.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b0e7d541-0b5c-5a78-aedd-65effbc4ab07","mechanism_event_label":"Calcium-sensitive kinase signaling contributed to electrical instability.","subject":{"id":"65e7fcad-670f-5dba-8488-896c86f2bbae","slug":"extracellular-potassium-concentration","display_name":"Extracellular potassium concentration","entity_type_key":"cellular_process"},"object":{"id":"c91a8ec8-1efa-5253-bb4c-435b8575f1cd","slug":"camkii","display_name":"Ca2+/calmodulin-dependent protein kinase II family","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"b0e7d541-0b5c-5a78-aedd-65effbc4ab07","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-low-activates-camkii-event","event_type":"biochemical_relationship","label":"Calcium-sensitive kinase signaling contributed to electrical instability.","description":"Rabbit hearts exposed to 2.7 mM K showed increased CaMKII activity; KN-93 prevented low-K early afterdepolarizations and ventricular arrhythmia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"kinase-linked signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"056cfa86-b026-53e4-ab37-4c3c3f996681","slug":"kn-93","display_name":"KN-93","entity_type_key":"small_molecule"},"role":"inhibitor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"76d6f9df-e38c-5537-b72a-e5dfd55dcdae","slug":"dofetilide","display_name":"Dofetilide","entity_type_key":"small_molecule"},"role":"separate sensitizing exposure","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"65e7fcad-670f-5dba-8488-896c86f2bbae","slug":"extracellular-potassium-concentration","display_name":"Extracellular potassium concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c91a8ec8-1efa-5253-bb4c-435b8575f1cd","slug":"camkii","display_name":"Ca2+/calmodulin-dependent protein kinase II family","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [pezhouman-2015-camkii] Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation (2015). https://pubmed.ncbi.nlm.nih.gov/26269574/ DOI: 10.1161/CIRCULATIONAHA.115.016217","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}