{"id":"4c64617f-0985-5e94-a134-40aefd4b14a1","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-kiwifruit-neutrophil-chemotaxis","predicate":"is-associated-with-increased","statement":"Following the four-week kiwifruit intervention, stimulated neutrophil chemotaxis increased about 20% in paired ex vivo assays (n=12, p=0.041); unstimulated migration did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9311573f-e088-5d80-9df5-54440cccbddd","mechanism_event_label":"Participants’ isolated neutrophils moved more effectively toward the laboratory stimulus after the intervention.","subject":{"id":"f333f4a6-b705-5059-a0b6-d5dfe6d80616","slug":"sungold-kiwifruit-dietary-intervention","display_name":"Dietary SunGold kiwifruit intervention","entity_type_key":"cellular_process"},"object":{"id":"a67662f9-68ba-5e2c-bbd6-dd8f87e32724","slug":"neutrophil-chemotaxis","display_name":"Neutrophil chemotaxis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9311573f-e088-5d80-9df5-54440cccbddd","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-transport-kiwifruit-neutrophil-chemotaxis-event","event_type":"observed_intervention","label":"Participants’ isolated neutrophils moved more effectively toward the laboratory stimulus after the intervention.","description":"Following the four-week kiwifruit intervention, stimulated neutrophil chemotaxis increased about 20% in paired ex vivo assays (n=12, p=0.041); unstimulated migration did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"candidate contributing nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f333f4a6-b705-5059-a0b6-d5dfe6d80616","slug":"sungold-kiwifruit-dietary-intervention","display_name":"Dietary SunGold kiwifruit intervention","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a67662f9-68ba-5e2c-bbd6-dd8f87e32724","slug":"neutrophil-chemotaxis","display_name":"Neutrophil chemotaxis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young men with suboptimal plasma vitamin C; before/after kiwifruit intervention and isolated neutrophils","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Two SunGold kiwifruit/day for four weeks in men with initially suboptimal plasma vitamin C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled whole-food intervention; assay improvement does not establish fewer infections or a vitamin C-specific causal mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Participants’ isolated neutrophils moved more effectively toward the laboratory stimulus after the intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[bozonet2015] Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. (2015). https://pubmed.ncbi.nlm.nih.gov/25912037/ DOI: 10.3390/nu7042574","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Isolated peripheral-blood neutrophils","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7888f31f-ea88-50e1-9736-e700282c7a38","evidence_kind":"source_excerpt","locator":"Lines 559-570","start_line":559,"end_line":570,"excerpt":"### vc-transport-kiwifruit-neutrophil-chemotaxis\nFollowing the four-week kiwifruit intervention, stimulated neutrophil chemotaxis increased about 20% in paired ex vivo assays (n=12, p=0.041); unstimulated migration did not change.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Participants’ isolated neutrophils moved more effectively toward the laboratory stimulus after the intervention.\norganism: Homo sapiens\ntissue_or_cell_type: Isolated peripheral-blood neutrophils\nexperimental_model: Young men with suboptimal plasma vitamin C; before/after kiwifruit intervention and isolated neutrophils\nlimitations: Uncontrolled whole-food intervention; assay improvement does not establish fewer infections or a vitamin C-specific causal mechanism.\nexposure: Two SunGold kiwifruit/day for four weeks in men with initially suboptimal plasma vitamin C\ncross_nutrient: false\n[bozonet2015] Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. (2015). https://pubmed.ncbi.nlm.nih.gov/25912037/ DOI: 10.3390/nu7042574","model_system":"Young men with suboptimal plasma vitamin C; before/after kiwifruit intervention and isolated neutrophils","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [bozonet2015] Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. (2015). https://pubmed.ncbi.nlm.nih.gov/25912037/ DOI: 10.3390/nu7042574","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}