{"id":"4bf39188-d4de-513d-8503-83c3e30acd86","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-iodine-context-thyroid-volume","predicate":"supplementation_reduces","statement":"Thyroid volume and thyroglobulin decreased with vitamin A alone; total T4 showed no significant treatment-interaction effect.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6815e3d2-a995-59ba-ba00-0f685edfc25a","mechanism_event_label":"Reduced thyroid enlargement did not establish a universal rise in thyroid hormone.","subject":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"object":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6815e3d2-a995-59ba-ba00-0f685edfc25a","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-iodine-context-thyroid-volume-event","event_type":"observed_intervention","label":"Reduced thyroid enlargement did not establish a universal rise in thyroid hormone.","description":"Thyroid volume and thyroglobulin decreased with vitamin A alone; total T4 showed no significant treatment-interaction effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"cointervention_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"bounded_null_interaction_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-zimmermann2007-iodine] Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate (2007). https://pubmed.ncbi.nlm.nih.gov/17921382/ DOI: 10.1093/ajcn/86.4.1040","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}