{"id":"4be5b12e-550e-5f8d-b649-8d039608fb03","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-night-vision-subgroup","predicate":"cointervention_may_improve","statement":"In women with low initial zinc, vitamin A plus zinc improved night-vision recovery versus double placebo; zinc alone did not.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cee73a0f-f778-513f-82e9-77def9eff6dd","mechanism_event_label":"An additional shortage may limit the response, but this result was subgroup-specific.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"334092e5-f575-582a-b64f-99aa53e42b2e","slug":"night-vision","display_name":"Night vision","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cee73a0f-f778-513f-82e9-77def9eff6dd","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-night-vision-subgroup-event","event_type":"observed_intervention","label":"An additional shortage may limit the response, but this result was subgroup-specific.","description":"In women with low initial zinc, vitamin A plus zinc improved night-vision recovery versus double placebo; zinc alone did not.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"status_measure","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"334092e5-f575-582a-b64f-99aa53e42b2e","slug":"night-vision","display_name":"Night vision","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Zinc/vitamin A -> dark-adaptation response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-week zinc randomization, existing vitamin A allocation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a universal zinc requirement; relative estimate had a wide confidence interval.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An additional shortage may limit the response, but this result was subgroup-specific.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-christian2001] Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women (2001). https://pubmed.ncbi.nlm.nih.gov/11382658/ DOI: 10.1093/ajcn/73.6.1045","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human visual function","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8ab2ce13-212c-5a37-b79b-b739681aae68","evidence_kind":"source_excerpt","locator":"Lines 1507-1517","start_line":1507,"end_line":1517,"excerpt":"### va-zinc-night-vision-subgroup\nIn women with low initial zinc, vitamin A plus zinc improved night-vision recovery versus double placebo; zinc alone did not.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An additional shortage may limit the response, but this result was subgroup-specific.\norganism: Homo sapiens\ntissue_or_cell_type: Human visual function\nexperimental_model: Three-week zinc randomization, existing vitamin A allocation.\nlimitations: Not a universal zinc requirement; relative estimate had a wide confidence interval.\ncross_nutrient: Zinc/vitamin A -> dark-adaptation response.\n[va-christian2001] Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women (2001). https://pubmed.ncbi.nlm.nih.gov/11382658/ DOI: 10.1093/ajcn/73.6.1045","model_system":"Three-week zinc randomization, existing vitamin A allocation.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-christian2001] Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women (2001). https://pubmed.ncbi.nlm.nih.gov/11382658/ DOI: 10.1093/ajcn/73.6.1045","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}