{"id":"4bc82aa9-e36a-5804-a19f-e45fd3043661","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-castor-starvation","predicate":"mediates_deprivation_response","statement":"CASTOR1 was required for arginine deprivation to inhibit mTORC1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8cebc469-1e5b-559b-8525-85098de573fe","mechanism_event_label":"Low arginine is sensed through specific machinery.","subject":{"id":"bcea5dc3-78e0-59c6-9d0d-52b90f980fe5","slug":"castor1","display_name":"Human cellular arginine sensor CASTOR1","entity_type_key":"protein"},"object":{"id":"9f025af3-f039-517f-908b-4af6fc65415e","slug":"mtorc1","display_name":"Mechanistic target of rapamycin complex 1","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"8cebc469-1e5b-559b-8525-85098de573fe","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-castor-starvation-event","event_type":"observed_relationship","label":"Low arginine is sensed through specific machinery.","description":"CASTOR1 was required for arginine deprivation to inhibit mTORC1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bcea5dc3-78e0-59c6-9d0d-52b90f980fe5","slug":"castor1","display_name":"Human cellular arginine sensor CASTOR1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f025af3-f039-517f-908b-4af6fc65415e","slug":"mtorc1","display_name":"Mechanistic target of rapamycin complex 1","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9bc75d40-8d7f-5314-aaf3-2dbf08db974c","slug":"arginine-depleted-medium","display_name":"Experimental arginine-depleted culture medium","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6fd39a83-0df1-562f-9bb8-f52553bcabf5","slug":"gator2","display_name":"Human GATOR2 complex","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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primary-abstract references and experimental limitations individually identified. 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