{"id":"4b92afd6-79de-5554-8acb-9c313fa29893","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:pyrophosphate-restrains-mineral-deposition","predicate":"inhibits","statement":"In Alpl-deficient mice and osteoblast preparations, excess pyrophosphate accompanied poor mineralization; removing Enpp1 normalized pyrophosphate and improved mineral deposition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fc2ad181-110a-5f75-bffc-f0365d3cbb40","mechanism_event_label":"Mineral formation depends on controlling an inhibitor as well as supplying calcium.","subject":{"id":"cd026fef-529f-5e03-b6b5-37ede8ce9127","slug":"pyrophosphate","display_name":"Inorganic pyrophosphate","entity_type_key":"small_molecule"},"object":{"id":"f8b4bc7f-edd0-511e-a3b3-c0191d216959","slug":"skeletal-mineralization","display_name":"Skeletal matrix mineralization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fc2ad181-110a-5f75-bffc-f0365d3cbb40","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:pyrophosphate-restrains-mineral-deposition-event","event_type":"biochemical_relationship","label":"Mineral formation depends on controlling an inhibitor as well as supplying calcium.","description":"In Alpl-deficient mice and osteoblast preparations, excess pyrophosphate accompanied poor mineralization; 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