{"id":"4b8f124c-3d6c-5864-8a19-f4c827bba295","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-r-racemate-exposure","predicate":"had_comparable_r_exposure_to","statement":"600 mg R-lipoic acid and 1200 mg racemate yielded bioequivalent R-enantiomer exposure in this crossover study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"55cb18ff-af3e-5837-a572-d1dbf4a4596a","mechanism_event_label":"Matching the amount of the R form produced similar measured R exposure.","subject":{"id":"8eeb8f85-a924-5122-9399-a757b83c668c","slug":"r-lipoic-acid","display_name":"Free R-alpha-lipoic acid","entity_type_key":"small_molecule"},"object":{"id":"74d37b34-076b-5697-87bd-17d63b4bdd02","slug":"racemic-lipoic-acid","display_name":"R,S-alpha-lipoic acid mixture","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"55cb18ff-af3e-5837-a572-d1dbf4a4596a","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-r-racemate-exposure-event","event_type":"observed_intervention","label":"Matching the amount of the R form produced similar measured R exposure.","description":"600 mg R-lipoic acid and 1200 mg racemate yielded bioequivalent R-enantiomer exposure in this crossover study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8eeb8f85-a924-5122-9399-a757b83c668c","slug":"r-lipoic-acid","display_name":"Free R-alpha-lipoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"74d37b34-076b-5697-87bd-17d63b4bdd02","slug":"racemic-lipoic-acid","display_name":"R,S-alpha-lipoic acid mixture","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ala-research/32212340.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"44984e6b01b34f66b48a24660a08befba9fc1691954a6832010d6ec01df29220\", \"start_char\": 0, \"end_char\": 1654, \"text_sha256\": \"44984e6b01b34f66b48a24660a08befba9fc1691954a6832010d6ec01df29220\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover study in 20 people with progressive multiple sclerosis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"600 mg R-lipoic acid versus 1200 mg racemic lipoic acid over 7–10 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Equal nominal R content but different total doses; short tolerability/PK study, not an efficacy comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Matching the amount of the R form produced similar measured R exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ala-p32212340] Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32212340/ DOI: 10.1002/jcph.1605","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and gastrointestinal symptom reports","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a78ab71c-c3c2-562b-9bc6-84d2a35a321d","evidence_kind":"source_excerpt","locator":"Lines 689-700","start_line":689,"end_line":700,"excerpt":"### ala-r-racemate-exposure\n600 mg R-lipoic acid and 1200 mg racemate yielded bioequivalent R-enantiomer exposure in this crossover study.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Matching the amount of the R form produced similar measured R exposure.\norganism: Human\ntissue_or_cell_type: Plasma and gastrointestinal symptom reports\nexperimental_model: Crossover study in 20 people with progressive multiple sclerosis\nlimitations: Equal nominal R content but different total doses; short tolerability/PK study, not an efficacy comparison.\nexposure: 600 mg R-lipoic acid versus 1200 mg racemic lipoic acid over 7–10 days\nevidence_span: {\"source_cache\": \"artifacts/ala-research/32212340.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"44984e6b01b34f66b48a24660a08befba9fc1691954a6832010d6ec01df29220\", \"start_char\": 0, \"end_char\": 1654, \"text_sha256\": \"44984e6b01b34f66b48a24660a08befba9fc1691954a6832010d6ec01df29220\"}\n[ala-p32212340] Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial. 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