{"id":"4b7219c5-90b6-522f-8539-dbde4f33f95b","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-supplement-calcitriol-no-baseline-interaction","predicate":"did_not_show_baseline_interaction_for","statement":"The trial did not detect a treatment-by-baseline-25(OH)D interaction for plasma calcitriol.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4df028d2-91e3-5cfb-896d-2135db200647","mechanism_event_label":"A change in stored vitamin D did not establish the same pattern for its active form.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"c2a6dfd2-6d61-5dcb-b263-1c16763e9c22","slug":"plasma-calcitriol-concentration","display_name":"Plasma calcitriol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4df028d2-91e3-5cfb-896d-2135db200647","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-supplement-calcitriol-no-baseline-interaction-event","event_type":"observed_intervention","label":"A change in stored vitamin D did not establish the same pattern for its active form.","description":"The trial did not detect a treatment-by-baseline-25(OH)D interaction for plasma calcitriol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c2a6dfd2-6d61-5dcb-b263-1c16763e9c22","slug":"plasma-calcitriol-concentration","display_name":"Plasma calcitriol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Magnesium/vitamin D: distinguish 25(OH)D from 1,25(OH)2D.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same randomized ancillary analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No significant interaction is not proof of no possible effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A change in stored vitamin D did not establish the same pattern for its active form.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b61a6b1-3078-5809-9167-ccc2df182157","evidence_kind":"source_excerpt","locator":"Lines 1443-1453","start_line":1443,"end_line":1453,"excerpt":"### mg-supplement-calcitriol-no-baseline-interaction\nThe trial did not detect a treatment-by-baseline-25(OH)D interaction for plasma calcitriol.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A change in stored vitamin D did not establish the same pattern for its active form.\norganism: Homo sapiens\ntissue_or_cell_type: Human plasma\nexperimental_model: Same randomized ancillary analysis.\nlimitations: No significant interaction is not proof of no possible effect.\ncross_nutrient: Magnesium/vitamin D: distinguish 25(OH)D from 1,25(OH)2D.\n[mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","model_system":"Same randomized ancillary analysis.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-dai2018] Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018). https://pubmed.ncbi.nlm.nih.gov/30541089/ DOI: 10.1093/ajcn/nqy274","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}