{"id":"4b70d589-2d72-5a7f-b001-9203bf8f8bad","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-high-calorie-mouse-survival","predicate":"improves","statement":"Resveratrol improved survival and several metabolic measures in middle-aged mice on a high-calorie diet compared with high-calorie controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c4e8e87b-8652-58fd-8472-afd809f591b0","mechanism_event_label":"Rescuing diet-associated harm is a specific survival result.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"7edb640c-1983-5919-9258-528c655359ee","slug":"mouse-high-calorie-diet-survival","display_name":"Survival of high-calorie-fed mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c4e8e87b-8652-58fd-8472-afd809f591b0","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-high-calorie-mouse-survival-event","event_type":"observed_relationship","label":"Rescuing diet-associated harm is a specific survival result.","description":"Resveratrol improved survival and several metabolic measures in middle-aged mice on a high-calorie diet compared with high-calorie controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7edb640c-1983-5919-9258-528c655359ee","slug":"mouse-high-calorie-diet-survival","display_name":"Survival of high-calorie-fed mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"High-calorie mouse model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not proof of lifespan extension in healthy humans or all mouse diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Rescuing diet-associated harm is a specific survival result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol improves health and survival of mice on a high-calorie diet. · 2006 · https://pubmed.ncbi.nlm.nih.gov/17086191/ · DOI 10.1038/nature05354","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"35dafd07-ada1-504e-96bc-8499db1b9767","evidence_kind":"source_excerpt","locator":"Lines 494-500","start_line":494,"end_line":500,"excerpt":"## resveratrol-high-calorie-mouse-survival\nRescuing diet-associated harm is a specific survival result.\nResveratrol improved survival and several metabolic measures in middle-aged mice on a high-calorie diet compared with high-calorie controls.\nModel: High-calorie mouse model.\nLimitations: Not proof of lifespan extension in healthy humans or all mouse diets.\nEvidence access: Primary abstract\nResveratrol improves health and survival of mice on a high-calorie diet. · 2006 · https://pubmed.ncbi.nlm.nih.gov/17086191/ · DOI 10.1038/nature05354","model_system":"High-calorie mouse model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}