{"id":"4b5a2826-5035-5732-ac5a-445cf5e2c5d1","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-methionine-competition","predicate":"inhibits","statement":"Mucosal L-methionine inhibited threonine uptake in the pig jejunal transport experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"741a6b8d-5d51-5aec-86a6-e70420def40e","mechanism_event_label":"A different essential amino acid can compete at the intestinal transport step.","subject":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"object":{"id":"dc066cde-6115-58b7-b5b3-35e35316f52a","slug":"pig-jejunal-threonine-uptake","display_name":"Pig jejunal apical threonine uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"741a6b8d-5d51-5aec-86a6-e70420def40e","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-methionine-competition-event","event_type":"observed_relationship","label":"A different essential amino acid can compete at the intestinal transport step.","description":"Mucosal L-methionine inhibited threonine uptake in the pig jejunal transport experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dc066cde-6115-58b7-b5b3-35e35316f52a","slug":"pig-jejunal-threonine-uptake","display_name":"Pig jejunal apical threonine uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ex vivo pig tissue; amino-acid uptake inhibition experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not show that normal methionine intake causes human threonine deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A different essential amino acid can compete at the intestinal transport step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transport of Neutral Amino Acids in the Jejunum of Pigs with Special Consideration of L-Methionine. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39408384/ · DOI 10.3390/nu16193418","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cbc74687-5b05-5547-b255-8e032d8c6d6d","evidence_kind":"source_excerpt","locator":"Lines 50-56","start_line":50,"end_line":56,"excerpt":"## l-threonine-methionine-competition\nA different essential amino acid can compete at the intestinal transport step.\nMucosal L-methionine inhibited threonine uptake in the pig jejunal transport experiments.\nModel: Ex vivo pig tissue; amino-acid uptake inhibition experiment.\nLimitations: This does not show that normal methionine intake causes human threonine deficiency.\nEvidence access: Primary abstract\nTransport of Neutral Amino Acids in the Jejunum of Pigs with Special Consideration of L-Methionine. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39408384/ · DOI 10.3390/nu16193418","model_system":"Ex vivo pig tissue; amino-acid uptake inhibition experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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