{"id":"4b589492-fe14-5fe8-b311-c7b8316bf9a5","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-coagulation-null","predicate":"no_detected_change_in_recorded_comparison","statement":"The small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"2261d19c-e338-50d2-9002-be041bd18400","mechanism_event_label":"The small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.","subject":{"id":"c87b0e7a-3012-55a0-a3d1-ffaf1a357e44","slug":"chamomile-coagulation-study-2023","display_name":"Chamomile tea or extract in the 2023 healthy-volunteer crossover study","entity_type_key":"botanical"},"object":{"id":"2accdb3d-4334-5a8b-a878-ff86e6b35f11","slug":"api-human-chamomile-coagulation","display_name":"Coagulation tests in the healthy-volunteer chamomile study","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"2261d19c-e338-50d2-9002-be041bd18400","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-coagulation-null-event","event_type":"experimental_observation","label":"The small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.","description":"### api-chamomile-coagulation-null\n\nThe small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.\nNo warfarin coadministration: this cannot exclude a warfarin interaction. It is not evidence about isolated apigenin.\nModel and exposure: 12 healthy volunteers; seven-day arms including nine tea bags/day or extract three times daily.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37730613/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC10510223/ | https://doi.org/10.1186/s13741-023-00339-7 | Access: Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c87b0e7a-3012-55a0-a3d1-ffaf1a357e44","slug":"chamomile-coagulation-study-2023","display_name":"Chamomile tea or extract in the 2023 healthy-volunteer crossover study","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Chamomile tea or extract","sequence_order":0,"notes":""},{"entity":{"id":"2accdb3d-4334-5a8b-a878-ff86e6b35f11","slug":"api-human-chamomile-coagulation","display_name":"Coagulation tests in the healthy-volunteer chamomile study","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Chamomile tea or extract\", \"comparator\": \"Placebo/control arm\", \"endpoint\": \"The small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"12 healthy volunteers; seven-day arms including nine tea bags/day or extract three times daily.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial. | https://pubmed.ncbi.nlm.nih.gov/37730613/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC10510223/ | https://doi.org/10.1186/s13741-023-00339-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-chamomile-coagulation-null; No warfarin coadministration: this cannot exclude a warfarin interaction. It is not evidence about isolated apigenin.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a022e95c-134e-5cbd-a084-1e7a6038a1ad","evidence_kind":"source_excerpt","locator":"Lines 936-942","start_line":936,"end_line":942,"excerpt":"### api-chamomile-coagulation-null\n\nThe small crossover study found no significant change in its coagulation endpoints after chamomile tea or extract.\nNo warfarin coadministration: this cannot exclude a warfarin interaction. It is not evidence about isolated apigenin.\nModel and exposure: 12 healthy volunteers; seven-day arms including nine tea bags/day or extract three times daily.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37730613/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC10510223/ | https://doi.org/10.1186/s13741-023-00339-7 | Access: Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","model_system":"12 healthy volunteers; seven-day arms including nine tea bags/day or extract three times daily.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}