{"id":"4b107581-e78a-5935-89c5-7baf15176923","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-occludin","predicate":"changes_regulation","statement":"In heated intestinal-cell models, zinc-carnosine increased total occludin and reduced measured occludin phosphorylation changes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"93f8b8f1-8bff-5a62-b8fc-15b9531a6341","mechanism_event_label":"Tight-junction proteins offered a possible explanation.","subject":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"object":{"id":"f150cead-8bcd-5b7f-8b13-5077e19c6516","slug":"human-ocln","display_name":"Human occludin / OCLN","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"93f8b8f1-8bff-5a62-b8fc-15b9531a6341","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-occludin-event","event_type":"observed_relationship","label":"Tight-junction proteins offered a possible explanation.","description":"In heated intestinal-cell models, zinc-carnosine increased total occludin and reduced measured occludin phosphorylation changes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f150cead-8bcd-5b7f-8b13-5077e19c6516","slug":"human-ocln","display_name":"Human occludin / OCLN","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ac12d3c9-07fb-5a19-bb89-1d44d9c2531a","slug":"human-heated-epithelial-resistance","display_name":"Human cultured intestinal epithelial resistance during heating","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human Caco-2/HT29 cell models with a 2-degree temperature increase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell experiments do not prove this mediated the volunteer outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; 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