{"id":"4b07d9a6-bbf8-53b7-9a71-987b37607508","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pparg-nos2","predicate":"loss_increases","statement":"Loss of epithelial PPAR-gamma signaling increased Nos2 expression and colonic nitrate availability in the mouse study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"98ff3f77-3084-5770-a4b0-de22c96ae5e9","mechanism_event_label":"Changing host signaling supplied a different bacterial respiratory fuel.","subject":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"object":{"id":"7fb7f2e6-3ddc-554c-bb45-8213d108582f","slug":"mouse-nos2","display_name":"Mouse inducible nitric oxide synthase / Nos2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"98ff3f77-3084-5770-a4b0-de22c96ae5e9","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pparg-nos2-event","event_type":"observed_relationship","label":"Changing host signaling supplied a different bacterial respiratory fuel.","description":"Loss of epithelial PPAR-gamma signaling increased Nos2 expression and colonic nitrate availability in the mouse study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7fb7f2e6-3ddc-554c-bb45-8213d108582f","slug":"mouse-nos2","display_name":"Mouse inducible nitric oxide synthase / Nos2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e4a04b78-1047-5ea7-b461-83860bb2de65","slug":"mouse-luminal-nitrate","display_name":"Mouse colonic luminal nitrate availability","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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