{"id":"4af6f7b3-9070-5edc-a8ac-ef7a1501976e","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-glytrp-bypass","predicate":"bypasses_single_amino_acid_transport_failure","statement":"Gly-Trp feeding restored serum tryptophan and reduced DSS-colitis susceptibility in Ace2-deficient mice, bypassing loss of single-amino-acid uptake.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"373e3213-f592-5db5-b109-423af0853f54","mechanism_event_label":"A dipeptide delivery route bypassed missing transport support.","subject":{"id":"bbe427ce-7765-58b2-a39f-d9b568f32daa","slug":"glycyl-l-tryptophan","display_name":"Glycyl-L-tryptophan / Gly-Trp dipeptide","entity_type_key":"small_molecule"},"object":{"id":"8cb2bb35-537a-5db0-b138-94506b1303d1","slug":"mouse-trp-colitis-susceptibility","display_name":"Mouse susceptibility to chemically induced colitis in tryptophan experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"373e3213-f592-5db5-b109-423af0853f54","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-glytrp-bypass-event","event_type":"observed_relationship","label":"A dipeptide delivery route bypassed missing transport support.","description":"Gly-Trp feeding restored serum tryptophan and reduced DSS-colitis susceptibility in Ace2-deficient mice, bypassing loss of single-amino-acid uptake.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bbe427ce-7765-58b2-a39f-d9b568f32daa","slug":"glycyl-l-tryptophan","display_name":"Glycyl-L-tryptophan / Gly-Trp dipeptide","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8cb2bb35-537a-5db0-b138-94506b1303d1","slug":"mouse-trp-colitis-susceptibility","display_name":"Mouse susceptibility to chemically induced colitis in tryptophan experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"51b5a82d-32e8-5223-b384-026dd7cead16","slug":"mouse-ace2","display_name":"Mouse angiotensin-converting enzyme 2 / Ace2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b987295b-26b7-5c9a-a033-c5e6ce272186","slug":"mouse-slc6a19","display_name":"Mouse B0AT1 / Slc6a19","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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primary-abstract references and experimental limitations individually identified. 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