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95% CI 0.68–0.93).\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding folic acid improved the first-stroke endpoint in this particular hypertensive population.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person clinical endpoints\nexperimental_model: Double-blind randomized CSPPT: 20702 Chinese adults with hypertension and no previous stroke or myocardial infarction, stratified by MTHFR C677T genotype.\nlimitations: Not a trial in all populations or secondary prevention; no proof of a single homocysteine-mediated mechanism.\nexposure: Enalapril 10 mg plus folic acid 0.8 mg/day versus enalapril alone; median 4.5 years.\n[fol-csppt2015] Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial (2015). https://pubmed.ncbi.nlm.nih.gov/25771069/ DOI: 10.1001/jama.2015.2274","model_system":"Double-blind randomized CSPPT: 20702 Chinese adults with hypertension and no previous stroke or myocardial infarction, stratified by MTHFR C677T genotype.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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