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The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Type 2 diabetic and control mice; mouse primary-cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The chain reaches a regulator of bone-resorbing cell formation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. (2026). https://pubmed.ncbi.nlm.nih.gov/41407214/ DOI: 10.1016/j.bbadis.2025.168139","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Neutrophil-to-macrophage signaling and osteoclastogenesis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ca28702e-5731-567c-aa74-dc7c938fa192","evidence_kind":"source_excerpt","locator":"Lines 458-469","start_line":458,"end_line":469,"excerpt":"### nasunin-pou2f2-fos\nPOU2F2 promoted osteoclastogenesis through c-Fos induction.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The chain reaches a regulator of bone-resorbing cell formation.\norganism: Type 2 diabetic and control mice; mouse primary-cell models\ntissue_or_cell_type: Neutrophil-to-macrophage signaling and osteoclastogenesis\nexperimental_model: Mouse transfer/ablation experiments, cell assays and virtual screening\nlimitations: New preclinical study: virtual screening nomination is not a measured binding affinity. The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.\nexposure: Nasunin intervention reported; exact regimen and binding validation unavailable in the indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/41407214.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\", \"start_char\": 0, \"end_char\": 1949, \"text_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\"}\n[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. 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