{"id":"4a4293d0-b7b5-56f9-8559-b242a5912a74","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-nitro-12","predicate":"coadministration_increases","statement":"Adding CLA during labeled oral nitrite administration increased plasma 12-nitro-CLA formation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a0f7208-31b9-5b19-ac53-564133b6355e","mechanism_event_label":"A second nitrated product was detected separately.","subject":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"object":{"id":"51cb409f-c0aa-5665-ac2e-e847bb4391e6","slug":"12-nitro-cla","display_name":"12-Nitro-conjugated linoleic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8a0f7208-31b9-5b19-ac53-564133b6355e","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-nitro-12-event","event_type":"observed_relationship","label":"A second nitrated product was detected separately.","description":"Adding CLA during labeled oral nitrite administration increased plasma 12-nitro-CLA formation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"51cb409f-c0aa-5665-ac2e-e847bb4391e6","slug":"12-nitro-cla","display_name":"12-Nitro-conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"03ffed32-aa18-5d63-96a4-8a7ebedaf7a9","slug":"nitrite","display_name":"Nitrite / NO2(-)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same five-person paired coadministration study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same dataset as the 9-nitro product, not an independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A second nitrated product was detected separately.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28739973/ · DOI 10.1161/HYPERTENSIONAHA.117.09016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8a4940dc-dc16-59be-87d1-235e72498bfb","evidence_kind":"source_excerpt","locator":"Lines 326-332","start_line":326,"end_line":332,"excerpt":"## cla-human-nitro-12\nA second nitrated product was detected separately.\nAdding CLA during labeled oral nitrite administration increased plasma 12-nitro-CLA formation.\nModel: Same five-person paired coadministration study.\nLimitations: Same dataset as the 9-nitro product, not an independent replication.\nEvidence access: Primary abstract\nConjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28739973/ · DOI 10.1161/HYPERTENSIONAHA.117.09016","model_system":"Same five-person paired coadministration study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}