{"id":"4a3a3985-2244-50fb-8f74-34584dd4bed8","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-tau-assembly","predicate":"reduces","statement":"The tested fulvic preparation reduced tau filament formation in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"afb25d4b-5ef1-5fdc-8bba-cfce3b2b779d","mechanism_event_label":"One preparation interfered with fibril assembly.","subject":{"id":"abe017d6-85cd-598c-91b3-3f5b4b87c543","slug":"tau-fulvic-preparation-2011","display_name":"Fulvic preparation in 2011 tau study, identity unresolved here","entity_type_key":"chemical_species"},"object":{"id":"174aaf2a-1e7e-5771-aa75-7fec24a248d3","slug":"tau-paired-helical-filament-assembly","display_name":"Tau paired-helical-filament assembly in vitro","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"afb25d4b-5ef1-5fdc-8bba-cfce3b2b779d","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-tau-assembly-event","event_type":"observed_relationship","label":"One preparation interfered with fibril assembly.","description":"The tested fulvic preparation reduced tau filament formation in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"abe017d6-85cd-598c-91b3-3f5b4b87c543","slug":"tau-fulvic-preparation-2011","display_name":"Fulvic preparation in 2011 tau study, identity unresolved here","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"174aaf2a-1e7e-5771-aa75-7fec24a248d3","slug":"tau-paired-helical-filament-assembly","display_name":"Tau paired-helical-filament assembly in vitro","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e6e12feb-ecfe-5217-8cfd-5184a502cceb","slug":"mapt","display_name":"Human microtubule-associated protein tau / MAPT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free tau aggregation and atomic-force microscopy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation identity and concentration are not resolved from the accessed abstract; no brain delivery or Alzheimer efficacy is demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"One preparation interfered with fibril assembly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785188/ · DOI 10.3233/JAD-2011-110623","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"116964a3-8c37-5447-9eed-36d49fe96b14","evidence_kind":"source_excerpt","locator":"Lines 148-154","start_line":148,"end_line":154,"excerpt":"## fulvic-acid-tau-assembly\nOne preparation interfered with fibril assembly.\nThe tested fulvic preparation reduced tau filament formation in vitro.\nModel: Cell-free tau aggregation and atomic-force microscopy.\nLimitations: Preparation identity and concentration are not resolved from the accessed abstract; no brain delivery or Alzheimer efficacy is demonstrated.\nEvidence access: Primary abstract\nFulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785188/ · DOI 10.3233/JAD-2011-110623","model_system":"Cell-free tau aggregation and atomic-force microscopy.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"52c2c3ee6bb23d943a40e1c39dd9de5cca7acd6efa72479cb824149e85cc7968","revision_id":"94dfc01b-c93e-55ff-8f48-bb2e9a1979f6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}