{"id":"499b084c-fc82-5e40-875e-d960a8880a6a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-diabetes-homa-trial2003","predicate":"repletion_lowered","statement":"Magnesium treatment lowered HOMA-IR compared with placebo in hypomagnesemic adults with type 2 diabetes receiving glibenclamide.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"df70305c-df18-5db3-b63e-d2bdccc68072","mechanism_event_label":"One trial found improved insulin-resistance estimates in a specific low-magnesium group.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"63223a9d-b872-57dd-b4b9-2085d2db023f","slug":"homa-insulin-resistance","display_name":"HOMA-IR estimate of insulin resistance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"df70305c-df18-5db3-b63e-d2bdccc68072","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-diabetes-homa-trial2003-event","event_type":"observed_intervention","label":"One trial found improved insulin-resistance estimates in a specific low-magnesium group.","description":"Magnesium treatment lowered HOMA-IR compared with placebo in hypomagnesemic adults with type 2 diabetes receiving glibenclamide.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"08c317e3-49bf-5254-a4f7-af1cd81695d7","slug":"magnesium-chloride","display_name":"Magnesium chloride","entity_type_key":"chemical_species"},"role":"studied_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"metabolic_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"metabolic_context","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"63223a9d-b872-57dd-b4b9-2085d2db023f","slug":"homa-insulin-resistance","display_name":"HOMA-IR estimate of insulin resistance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Magnesium -> insulin/glucose endpoints; treatment context matters.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"63-person, 16-week randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eligibility serum Mg at most 0.74 mmol/L. End-study HOMA-IR means 3.8 versus 5.0.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"HOMA is a surrogate, not a clamp; renal impairment was excluded. Not proof that all diabetes responds to Mg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One trial found improved insulin-resistance estimates in a specific low-magnesium group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-rodriguezmoran2003] Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial (2003). https://pubmed.ncbi.nlm.nih.gov/12663588/ DOI: 10.2337/diacare.26.4.1147","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood-based metabolic endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58afabfc-d1f8-5116-8de2-8ddd837f8074","evidence_kind":"source_excerpt","locator":"Lines 1551-1562","start_line":1551,"end_line":1562,"excerpt":"### mg-diabetes-homa-trial2003\nMagnesium treatment lowered HOMA-IR compared with placebo in hypomagnesemic adults with type 2 diabetes receiving glibenclamide.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One trial found improved insulin-resistance estimates in a specific low-magnesium group.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood-based metabolic endpoints\nexperimental_model: 63-person, 16-week randomized trial.\nlimitations: HOMA is a surrogate, not a clamp; renal impairment was excluded. Not proof that all diabetes responds to Mg.\ncross_nutrient: Magnesium -> insulin/glucose endpoints; treatment context matters.\nexposure: Eligibility serum Mg at most 0.74 mmol/L. End-study HOMA-IR means 3.8 versus 5.0.\n[mg-rodriguezmoran2003] Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial (2003). https://pubmed.ncbi.nlm.nih.gov/12663588/ DOI: 10.2337/diacare.26.4.1147","model_system":"63-person, 16-week randomized trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-rodriguezmoran2003] Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial (2003). https://pubmed.ncbi.nlm.nih.gov/12663588/ DOI: 10.2337/diacare.26.4.1147","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}