{"id":"497a09ae-9ef8-5eda-9b1a-6dbf7927fc68","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-hne-intact-peptide","predicate":"quenches","statement":"At pH 7.4, intact carnosine quenched HNE more effectively than histidine or N-acetylcarnosine, while beta-alanine was inactive.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"849d4f47-9eb0-5864-8f34-d1ea5c0c0718","mechanism_event_label":"The joined peptide has properties its separate parts do not reproduce.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"cc9bce9d-a834-5e6d-85a5-b873b8e69a21","slug":"4-hydroxynonenal","display_name":"4-Hydroxy-2-nonenal / HNE","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"849d4f47-9eb0-5864-8f34-d1ea5c0c0718","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-hne-intact-peptide-event","event_type":"observed_relationship","label":"The joined peptide has properties its separate parts do not reproduce.","description":"At pH 7.4, intact carnosine quenched HNE more effectively than histidine or N-acetylcarnosine, while beta-alanine was inactive.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc9bce9d-a834-5e6d-85a5-b873b8e69a21","slug":"4-hydroxynonenal","display_name":"4-Hydroxy-2-nonenal / HNE","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This molecular comparison is not proof of supplement synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The joined peptide has properties its separate parts do not reproduce.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction? · 2002 · https://pubmed.ncbi.nlm.nih.gov/12419310/ · DOI 10.1016/s0006-291x(02)02545-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"be84b184-3ce3-5ef6-8979-13bc46617cdf","evidence_kind":"source_excerpt","locator":"Lines 244-250","start_line":244,"end_line":250,"excerpt":"## carnosine-hne-intact-peptide\nThe joined peptide has properties its separate parts do not reproduce.\nAt pH 7.4, intact carnosine quenched HNE more effectively than histidine or N-acetylcarnosine, while beta-alanine was inactive.\nModel: Cell-free comparison.\nLimitations: This molecular comparison is not proof of supplement synergy.\nEvidence access: Primary abstract\nCarnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction? · 2002 · https://pubmed.ncbi.nlm.nih.gov/12419310/ · DOI 10.1016/s0006-291x(02)02545-7","model_system":"Cell-free comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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