{"id":"496c9410-b4bd-5bd9-874e-99588c69f20b","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-human-lovastatin-coq","predicate":"reduces_reported","statement":"The 1990 human lovastatin report observed reductions in circulating CoQ10 during drug exposure in five hospitalized patients and a separately monitored volunteer.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d5a951d2-763e-5ed6-9d7c-de20b90968a3","mechanism_event_label":"A constituent has human CoQ observations, with major study limitations.","subject":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"object":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5a951d2-763e-5ed6-9d7c-de20b90968a3","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-human-lovastatin-coq-event","event_type":"observed_relationship","label":"A constituent has human CoQ observations, with major study limitations.","description":"The 1990 human lovastatin report observed reductions in circulating CoQ10 during drug exposure in five hospitalized patients and a separately monitored volunteer.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small uncontrolled clinical series, including pre-existing cardiac disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish causal cardiomyopathy, tissue deficiency or the same effect from a specified red yeast rice product.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A constituent has human CoQ observations, with major study limitations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[2247468] Lovastatin decreases coenzyme Q levels in humans. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2247468/ · DOI 10.1073/pnas.87.22.8931","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1cd77808-36fb-525d-8356-a8ed16a3985d","evidence_kind":"source_excerpt","locator":"Lines 84-90","start_line":84,"end_line":90,"excerpt":"## red-yeast-rice-human-lovastatin-coq\nA constituent has human CoQ observations, with major study limitations.\nThe 1990 human lovastatin report observed reductions in circulating CoQ10 during drug exposure in five hospitalized patients and a separately monitored volunteer.\nModel: Small uncontrolled clinical series, including pre-existing cardiac disease.\nLimitations: Does not establish causal cardiomyopathy, tissue deficiency or the same effect from a specified red yeast rice product.\nEvidence access: Primary abstract\n[2247468] Lovastatin decreases coenzyme Q levels in humans. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2247468/ · DOI 10.1073/pnas.87.22.8931","model_system":"Small uncontrolled clinical series, including pre-existing cardiac disease.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}