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(2023). https://pubmed.ncbi.nlm.nih.gov/37834026/ DOI: 10.3390/ijms241914578","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"AhR-ERalpha co-regulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0adee7b-b0c4-5ea9-8cba-4f7f48d5b965","evidence_kind":"source_excerpt","locator":"Lines 649-660","start_line":649,"end_line":660,"excerpt":"### dim-ahr-er-crosstalk\nDIM produced overlapping AHR- and ERalpha-associated regulatory patterns, with preferential AHR recruitment to ERalpha targets when both receptors were activated.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Two receptors can cooperate on a response instead of acting as isolated switches.\norganism: Human MCF-7 cells\ntissue_or_cell_type: AhR-ERalpha co-regulation\nexperimental_model: ChIP sequencing and transcriptomics\nlimitations: Genome-wide cell-model binding and transcription; no patient efficacy or universal receptor hierarchy established.\nexposure: DIM, estradiol, TCDD and resveratrol comparisons\nevidence_span: {\"source_cache\": \"artifacts/dim-research/37834026.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b0f6f8f6c7fd2b3a09e9dd39b50c5e692c9bcca9b0119ab32475aff0685d2443\", \"start_char\": 0, \"end_char\": 1593, \"text_sha256\": \"b0f6f8f6c7fd2b3a09e9dd39b50c5e692c9bcca9b0119ab32475aff0685d2443\"}\n[dim-p37834026] Resveratrol and 3,3'-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells. 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