{"id":"4948c1db-d16f-5d3a-b81d-f81d1556e614","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-human-memory-null","predicate":"no_significant_primary_benefit","statement":"Twelve months of wheat-germ extract supplying 0.9 mg/day spermidine did not significantly improve the primary memory outcome versus placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"676fd6dd-fd0c-5576-9660-ef4fd71a4b2a","mechanism_event_label":"The longer human trial did not confirm its main memory hypothesis.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"33a36026-b4c7-565c-b1b6-03bdbf5ce7e4","slug":"human-smartage-memory-performance","display_name":"Human SmartAge mnemonic discrimination performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"676fd6dd-fd0c-5576-9660-ef4fd71a4b2a","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-human-memory-null-event","event_type":"observed_relationship","label":"The longer human trial did not confirm its main memory hypothesis.","description":"Twelve months of wheat-germ extract supplying 0.9 mg/day spermidine did not significantly improve the primary memory outcome versus placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"33a36026-b4c7-565c-b1b6-03bdbf5ce7e4","slug":"human-smartage-memory-performance","display_name":"Human SmartAge mnemonic discrimination performance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"100 adults aged 60–90 with subjective cognitive decline; randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extract rather than pure spermidine; dose and population specific. Difference -0.03, 95% CI -0.11 to 0.05, P=.47.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The longer human trial did not confirm its main memory hypothesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35616942/ · DOI 10.1001/jamanetworkopen.2022.13875","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0d687722-06a3-5c34-ac4f-1b3319c9d22f","evidence_kind":"source_excerpt","locator":"Lines 566-572","start_line":566,"end_line":572,"excerpt":"## spermidine-human-memory-null\nThe longer human trial did not confirm its main memory hypothesis.\nTwelve months of wheat-germ extract supplying 0.9 mg/day spermidine did not significantly improve the primary memory outcome versus placebo.\nModel: 100 adults aged 60–90 with subjective cognitive decline; randomized trial.\nLimitations: Extract rather than pure spermidine; dose and population specific. Difference -0.03, 95% CI -0.11 to 0.05, P=.47.\nEvidence access: Primary full text\nEffects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35616942/ · DOI 10.1001/jamanetworkopen.2022.13875","model_system":"100 adults aged 60–90 with subjective cognitive decline; randomized trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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