{"id":"48fcd557-40fa-5ade-81bd-3cb2cc974cec","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-mtrr-species-recognition","predicate":"selectively_supports","statement":"Human MTRR sustained human MTR, whereas bacterial flavodoxin/flavodoxin reductase did not significantly support the human enzyme.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"dd60b1c8-8a2d-55d6-99f8-94fd576ec939","mechanism_event_label":"The electron-donor partners were species selective.","subject":{"id":"a0be0dca-5f6e-54a8-b760-e59a0658207d","slug":"mtrr","display_name":"Methionine synthase reductase / MTRR","entity_type_key":"protein"},"object":{"id":"91aa077a-bfee-574d-9e5f-28da25239196","slug":"mtr","display_name":"Cobalamin-dependent methionine synthase / MTR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"dd60b1c8-8a2d-55d6-99f8-94fd576ec939","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-mtrr-species-recognition-event","event_type":"biochemical_relationship","label":"The electron-donor partners were species selective.","description":"Human MTRR sustained human MTR, whereas bacterial flavodoxin/flavodoxin reductase did not significantly support the human enzyme.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a0be0dca-5f6e-54a8-b760-e59a0658207d","slug":"mtrr","display_name":"Methionine synthase reductase / MTRR","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"91aa077a-bfee-574d-9e5f-28da25239196","slug":"mtr","display_name":"Cobalamin-dependent methionine synthase / MTR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human MTR/MTRR expressed in insect cells; purified enzymes and extracts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bacterial proteins are assay comparators.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The electron-donor partners were species selective.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[yamada-2006] Human methionine synthase reductase is a molecular chaperone for human methionine synthase (2006). https://pubmed.ncbi.nlm.nih.gov/16769880/ DOI: 10.1073/pnas.0603694103","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified proteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9d044e72-2551-5f48-ae86-20a6c176eb14","evidence_kind":"source_excerpt","locator":"Lines 506-515","start_line":506,"end_line":515,"excerpt":"### folate-methyl-mtrr-species-recognition\nHuman MTRR sustained human MTR, whereas bacterial flavodoxin/flavodoxin reductase did not significantly support the human enzyme.\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The electron-donor partners were species selective.\norganism: Homo sapiens\ntissue_or_cell_type: Purified proteins\nexperimental_model: Human MTR/MTRR expressed in insect cells; purified enzymes and extracts.\nlimitations: Bacterial proteins are assay comparators.\n[yamada-2006] Human methionine synthase reductase is a molecular chaperone for human methionine synthase (2006). https://pubmed.ncbi.nlm.nih.gov/16769880/ DOI: 10.1073/pnas.0603694103","model_system":"Human MTR/MTRR expressed in insect cells; purified enzymes and extracts.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [yamada-2006] Human methionine synthase reductase is a molecular chaperone for human methionine synthase (2006). https://pubmed.ncbi.nlm.nih.gov/16769880/ DOI: 10.1073/pnas.0603694103","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}