{"id":"48bc69cd-c6c3-5cfe-86a5-da3b9e18282a","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-boronate","predicate":"forms_adduct_with","statement":"NMR and cell experiments characterized boronate and borate EGCG–bortezomib derivatives; adduct stability depended on structural features.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5b6c15bc-82e8-559c-9feb-c9f2e3cf215d","mechanism_event_label":"The chemical interaction has evidence beyond a pathway diagram.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"7c75470d-e9e0-5a6b-b342-6a1201da6b13","slug":"bortezomib","display_name":"Bortezomib","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5b6c15bc-82e8-559c-9feb-c9f2e3cf215d","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-boronate-event","event_type":"observed_relationship","label":"The chemical interaction has evidence beyond a pathway diagram.","description":"NMR and cell experiments characterized boronate and borate EGCG–bortezomib derivatives; adduct stability depended on structural features.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7c75470d-e9e0-5a6b-b342-6a1201da6b13","slug":"bortezomib","display_name":"Bortezomib","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"17ae4bd3-4ae7-5d58-8aa6-3b13869532ef","slug":"egcg-bortezomib-adducts","display_name":"EGCG–bortezomib boronate and borate adducts","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Chemical characterization and cell assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A boronic-acid drug is not interchangeable with dietary boron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The chemical interaction has evidence beyond a pathway diagram.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25669488/ · DOI 10.1039/c4ob02512a","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"911efd2c-e0ce-58f9-837e-864f294fc581","evidence_kind":"source_excerpt","locator":"Lines 412-418","start_line":412,"end_line":418,"excerpt":"## egcg-boronate\nThe chemical interaction has evidence beyond a pathway diagram.\nNMR and cell experiments characterized boronate and borate EGCG–bortezomib derivatives; adduct stability depended on structural features.\nModel: Chemical characterization and cell assays.\nLimitations: A boronic-acid drug is not interchangeable with dietary boron.\nEvidence access: primary abstract.\nMolecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25669488/ · DOI 10.1039/c4ob02512a","model_system":"Chemical characterization and cell assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}