{"id":"4886056f-a839-56e2-8be1-8425c28a2ec0","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:selective-mg-depletion-impairs-pth-compensation","predicate":"depletion-blunts","statement":"After selective dietary Mg depletion, 20 of 26 adults showed unchanged or reduced PTH despite falling serum Mg and Ca.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"918e8d04-31cd-5c8c-b4bb-9fa7b849ab98","mechanism_event_label":"PTH compensation was impaired during an induced shortage, before a failed calcium-replacement attempt was needed to reveal it.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"918e8d04-31cd-5c8c-b4bb-9fa7b849ab98","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:selective-mg-depletion-impairs-pth-compensation-event","event_type":"biochemical_relationship","label":"PTH compensation was impaired during an induced shortage, before a failed calcium-replacement attempt was needed to reveal it.","description":"After selective dietary Mg depletion, 20 of 26 adults showed unchanged or reduced PTH despite falling serum Mg and Ca.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"falling compensatory stimulus","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"hormone endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"26 initially normal adults before/after three-week low-Mg diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Before/after experiment; not a population diagnostic rule. Depletion was supported by serum Mg, retention, and red-cell free Mg changes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"PTH compensation was impaired during an induced shortage, before a failed calcium-replacement attempt was needed to reveal it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood; parathyroid and renal mineral axis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"cec252de-ba0b-52c5-97ee-25ee3f407cb6","evidence_kind":"source_excerpt","locator":"Lines 361-371","start_line":361,"end_line":371,"excerpt":"### selective-mg-depletion-impairs-pth-compensation\nAfter selective dietary Mg depletion, 20 of 26 adults showed unchanged or reduced PTH despite falling serum Mg and Ca.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: PTH compensation was impaired during an induced shortage, before a failed calcium-replacement attempt was needed to reveal it.\norganism: Homo sapiens\ntissue_or_cell_type: Blood; parathyroid and renal mineral axis\nexperimental_model: 26 initially normal adults before/after three-week low-Mg diet\nlimitations: Before/after experiment; not a population diagnostic rule. Depletion was supported by serum Mg, retention, and red-cell free Mg changes.\ncross_nutrient: magnesium -> PTH -> calcium\n[fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","model_system":"26 initially normal adults before/after three-week low-Mg diet","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}