{"id":"48664202-61b8-5bd7-b050-21b5994dced5","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-isolated-constituent-cyp-selectivity","predicate":"inhibits","statement":"Several isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"af62c1fc-8107-5749-bbcf-31d58fa14621","mechanism_event_label":"Several isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.","subject":{"id":"077569ba-b74e-553b-a317-5a81c118ef90","slug":"moringa-isolated-cyp3a4-inhibitors","display_name":"Omoringone and other isolated Moringa leaf CYP3A4 inhibitors","entity_type_key":"chemical_species"},"object":{"id":"54e95ff1-4ffa-5e6f-a4cb-b47e5d2a5bda","slug":"cyp3a4","display_name":"Human cytochrome P450 3A4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"af62c1fc-8107-5749-bbcf-31d58fa14621","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-isolated-constituent-cyp-selectivity-event","event_type":"observed_relationship","label":"Several isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.","description":"Several isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"077569ba-b74e-553b-a317-5a81c118ef90","slug":"moringa-isolated-cyp3a4-inhibitors","display_name":"Omoringone and other isolated Moringa leaf CYP3A4 inhibitors","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"54e95ff1-4ffa-5e6f-a4cb-b47e5d2a5bda","slug":"cyp3a4","display_name":"Human cytochrome P450 3A4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"10f7a103-d63d-5bf4-8384-c5e1308ce126","slug":"cyp2d6","display_name":"Human cytochrome P450 2D6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Isolated constituents up to the assay range","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant or assay-system human CYP3A4/CYP2D6 panel","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bioavailability was unresolved, so these concentrations cannot be treated as expected human exposure or used to predict a specific medicine interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Recombinant or assay-system human CYP3A4/CYP2D6 panel","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Several isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Isolation, synthesis, and drug interaction potential of secondary metabolites derived from the leaves of miracle tree (Moringa oleifera) against CYP3A4 and CYP2D6 isozymes. (2019). https://pubmed.ncbi.nlm.nih.gov/31301970/ DOI: 10.1016/j.phymed.2019.153010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"CYP isozyme inhibition","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a12cfcf2-6582-5635-8abe-cdd8c1411ca3","evidence_kind":"source_excerpt","locator":"Lines 211-220","start_line":211,"end_line":220,"excerpt":"## moringa-isolated-constituent-cyp-selectivity\nSeveral isolated Moringa leaf metabolites inhibited CYP3A4 at 41.5-100 micromolar but showed no remarkable CYP2D6 inhibition in the same in-vitro panel.\nModel/species: Recombinant or assay-system human CYP3A4/CYP2D6 panel\nTissue/system: CYP isozyme inhibition\nExposure: Isolated constituents up to the assay range\nRoute: In vitro\nDuration: Acute\nLimits: Bioavailability was unresolved, so these concentrations cannot be treated as expected human exposure or used to predict a specific medicine interaction.\nPrimary reference: Isolation, synthesis, and drug interaction potential of secondary metabolites derived from the leaves of miracle tree (Moringa oleifera) against CYP3A4 and CYP2D6 isozymes. (2019). https://pubmed.ncbi.nlm.nih.gov/31301970/ DOI: 10.1016/j.phymed.2019.153010\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Recombinant or assay-system human CYP3A4/CYP2D6 panel","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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