{"id":"484d495d-d4ba-5a6d-a4b5-0e3863adfafc","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-organoid-lipid-toxicity","predicate":"injure","statement":"Deoxysphingolipid exposure caused photoreceptor-cell death in human retinal organoids, which was prevented by tested regulators of lipid metabolism.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c8cdefbf-5225-549d-9d6b-9674869ac01c","mechanism_event_label":"The abnormal lipid can itself damage cells in an experimental retinal model.","subject":{"id":"4d9df16d-24fa-5dc5-ab2a-2369a6a0399d","slug":"1-deoxysphingolipids","display_name":"1-Deoxysphingolipids","entity_type_key":"lipid"},"object":{"id":"d3be4dc8-bc02-5082-87e1-ed30bde84b36","slug":"human-retinal-organoid-photoreceptors","display_name":"Photoreceptor survival in human retinal organoids","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c8cdefbf-5225-549d-9d6b-9674869ac01c","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-organoid-lipid-toxicity-event","event_type":"observed_relationship","label":"The abnormal lipid can itself damage cells in an experimental retinal model.","description":"Deoxysphingolipid exposure caused photoreceptor-cell death in human retinal organoids, which was prevented by tested regulators of lipid metabolism.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4d9df16d-24fa-5dc5-ab2a-2369a6a0399d","slug":"1-deoxysphingolipids","display_name":"1-Deoxysphingolipids","entity_type_key":"lipid"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d3be4dc8-bc02-5082-87e1-ed30bde84b36","slug":"human-retinal-organoid-photoreceptors","display_name":"Photoreceptor survival in human retinal organoids","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human retinal organoid exposure experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The result does not establish effective serine treatment for people with MacTel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The abnormal lipid can itself damage cells in an experimental retinal model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31509666/ · DOI 10.1056/NEJMoa1815111","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"22f847cf-607b-5c8d-919c-7d442f24a6a4","evidence_kind":"source_excerpt","locator":"Lines 286-292","start_line":286,"end_line":292,"excerpt":"## l-serine-organoid-lipid-toxicity\nThe abnormal lipid can itself damage cells in an experimental retinal model.\nDeoxysphingolipid exposure caused photoreceptor-cell death in human retinal organoids, which was prevented by tested regulators of lipid metabolism.\nModel: Human retinal organoid exposure experiment.\nLimitations: The result does not establish effective serine treatment for people with MacTel.\nEvidence access: Primary abstract\nSerine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31509666/ · DOI 10.1056/NEJMoa1815111","model_system":"Human retinal organoid exposure experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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