{"id":"48005c23-156c-5146-916c-23bce251be1e","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:bone-amorphous-mineral-precursor-hypothesis","predicate":"proposed_precursor_of","statement":"Amorphous calcium phosphate in newly forming zebrafish fin bone and increasing crystallinity with maturation support an amorphous-precursor model.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"415a6519-527c-5e11-bb7b-2498ceb41f9f","mechanism_event_label":"A disordered calcium phosphate phase may precede organized bone crystals.","subject":{"id":"8a844f22-4cae-5cb0-8f8f-2c382a978170","slug":"amorphous-calcium-phosphate","display_name":"Amorphous calcium phosphate","entity_type_key":"chemical_species"},"object":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"415a6519-527c-5e11-bb7b-2498ceb41f9f","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:bone-amorphous-mineral-precursor-hypothesis-event","event_type":"biochemical_relationship","label":"A disordered calcium phosphate phase may precede organized bone crystals.","description":"Amorphous calcium phosphate in newly forming zebrafish fin bone and increasing crystallinity with maturation support an amorphous-precursor model.","status":"provisional","compartment":{"slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix"},"participants":[{"entity":{"id":"8a844f22-4cae-5cb0-8f8f-2c382a978170","slug":"amorphous-calcium-phosphate","display_name":"Amorphous calcium phosphate","entity_type_key":"chemical_species"},"role":"proposed_precursor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"role":"mature_mineral","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7dbb4c2f-3f94-5f0b-abfc-980d8a4105d5","slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix","entity_type_key":"tissue"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":2,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Bone extracellular matrix","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Spatial maturation series and extracted-particle crystallization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed sequence is not direct tracking of every mineral particle in living human bone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Danio rerio","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A disordered calcium phosphate phase may precede organized bone crystals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Growing fin-ray bone","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9678d67b-1685-5fa6-8a24-e0346d451283","evidence_kind":"source_excerpt","locator":"Lines 874-884","start_line":874,"end_line":884,"excerpt":"### bone-amorphous-mineral-precursor-hypothesis\nAmorphous calcium phosphate in newly forming zebrafish fin bone and increasing crystallinity with maturation support an amorphous-precursor model.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A disordered calcium phosphate phase may precede organized bone crystals.\norganism: Danio rerio\ntissue_or_cell_type: Growing fin-ray bone\nexperimental_model: Spatial maturation series and extracted-particle crystallization\nlimitations: The proposed sequence is not direct tracking of every mineral particle in living human bone.\ncompartment_description: Bone extracellular matrix\n[mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","model_system":"Spatial maturation series and extracted-particle crystallization","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}