{"id":"47f203e7-22ec-5a85-ae8d-6dd277e89f8d","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-malonyl-coa-fall","predicate":"reduces","statement":"At 4 hours after feeding, liver malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl-transferase, was significantly lower in the acetic acid group than in the control group, along with a lower serum lactate concentration and a lower ratio of insulin to glucagon, indicating the possibility of a transient enhancement of fatty acid oxidation in liver.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4aba27f9-b4fe-5047-9d53-1ff08e97d091","mechanism_event_label":"The brake on fat burning came off for a few hours.","subject":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"object":{"id":"52c778e0-2b9e-5ce2-8056-a0ffdd726693","slug":"malonyl-coa","display_name":"Malonyl-CoA","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"4aba27f9-b4fe-5047-9d53-1ff08e97d091","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-malonyl-coa-fall-event","event_type":"biochemical_relationship","label":"The brake on fat burning came off for a few hours.","description":"At 4 hours after feeding, liver malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl-transferase, was significantly lower in the acetic acid group than in the control group, along with a lower serum lactate concentration and a lower ratio of insulin to glucagon, indicating the possibility of a transient enhancement of fatty acid oxidation in liver.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73cef62a-fc2e-5072-9fff-402e58d165fa","slug":"fatty-acid-oxidation","display_name":"Cellular fatty acid oxidation","entity_type_key":"cellular_process"},"role":"released_process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"lowered_ratio_component","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"52c778e0-2b9e-5ce2-8056-a0ffdd726693","slug":"malonyl-coa","display_name":"Malonyl-CoA","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/acetate-research/16277773.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe\", \"start_char\": 0, \"end_char\": 1594, \"text_sha256\": \"305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rats meal-fed once daily for 10 days, then sampled 4, 8 or 24 hours after feeding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.7 g/kg-diet acetic acid in a 9 g meal, with sampling across the daily cycle","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Adds the time dimension that single-timepoint studies miss. The effects were present at 4 hours and the authors explicitly rule out supercompensation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The brake on fat burning came off for a few hours.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[acetate-p16277773] Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. 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The effects were present at 4 hours and the authors explicitly rule out supercompensation.\nexposure: 0.7 g/kg-diet acetic acid in a 9 g meal, with sampling across the daily cycle\nevidence_span: {\"source_cache\": \"artifacts/acetate-research/16277773.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe\", \"start_char\": 0, \"end_char\": 1594, \"text_sha256\": \"305aa81aca9908a350132a7c7dcc42c86be0b6030c70f51b5fe0c8971e75bcfe\"}\n[acetate-p16277773] Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. (2005). https://pubmed.ncbi.nlm.nih.gov/16277773/ DOI: 10.1079/bjn20051545","model_system":"Rats meal-fed once daily for 10 days, then sampled 4, 8 or 24 hours after feeding","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [acetate-p16277773] Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. 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