{"id":"4771de13-04d4-5cf8-bb37-e5200ceab021","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:primary-hypomagnesemia-can-preserve-pth-response","predicate":"retains-end-organ-response-in","statement":"A child with primary hypomagnesemia retained calcemic and renal phosphate/cAMP responses to parathyroid extract during Mg depletion despite impaired endogenous PTH secretion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fe1e6d68-4a99-5a06-8fd7-3ed129fb15e2","mechanism_event_label":"In this child the main failure was releasing the hormone; tissues could still respond when hormone was provided.","subject":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"object":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fe1e6d68-4a99-5a06-8fd7-3ed129fb15e2","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:primary-hypomagnesemia-can-preserve-pth-response-event","event_type":"biochemical_relationship","label":"In this child the main failure was releasing the hormone; tissues could still respond when hormone was provided.","description":"A child with primary hypomagnesemia retained calcemic and renal phosphate/cAMP responses to parathyroid extract during Mg depletion despite impaired endogenous PTH secretion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"restricted nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"role":"impaired upstream process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"46f1b617-0a8d-5dfe-b6fa-d5fd23745898","slug":"urinary-camp-excretion","display_name":"Urinary cyclic AMP excretion","entity_type_key":"cellular_process"},"role":"preserved renal response","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"renal response ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium/phosphate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-child Mg withdrawal/repletion with hormone challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single case; shows PTH resistance is not obligatory. Primary hypomagnesemia was not genetically assigned in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this child the main failure was releasing the hormone; tissues could still respond when hormone was provided.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[suh-1973-preserved-pth-response] Pathogenesis of Hypocalcemia in Primary Hypomagnesemia: Normal End-Organ Responsiveness to Parathyroid Hormone, Impaired Parathyroid Gland Function (1973). https://www.jci.org/articles/view/107159 DOI: 10.1172/JCI107159","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and kidney","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1deb9ca1-3356-5183-933f-f0931ddf140b","evidence_kind":"source_excerpt","locator":"Lines 397-407","start_line":397,"end_line":407,"excerpt":"### primary-hypomagnesemia-can-preserve-pth-response\nA child with primary hypomagnesemia retained calcemic and renal phosphate/cAMP responses to parathyroid extract during Mg depletion despite impaired endogenous PTH secretion.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this child the main failure was releasing the hormone; tissues could still respond when hormone was provided.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and kidney\nexperimental_model: Single-child Mg withdrawal/repletion with hormone challenge\nlimitations: Single case; shows PTH resistance is not obligatory. Primary hypomagnesemia was not genetically assigned in this study.\ncross_nutrient: magnesium -> PTH -> calcium/phosphate\n[suh-1973-preserved-pth-response] Pathogenesis of Hypocalcemia in Primary Hypomagnesemia: Normal End-Organ Responsiveness to Parathyroid Hormone, Impaired Parathyroid Gland Function (1973). https://www.jci.org/articles/view/107159 DOI: 10.1172/JCI107159","model_system":"Single-child Mg withdrawal/repletion with hormone challenge","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [suh-1973-preserved-pth-response] Pathogenesis of Hypocalcemia in Primary Hypomagnesemia: Normal End-Organ Responsiveness to Parathyroid Hormone, Impaired Parathyroid Gland Function (1973). https://www.jci.org/articles/view/107159 DOI: 10.1172/JCI107159","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}