{"id":"47618683-bcf7-54d0-932d-aca221824a0f","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-vitamin-c","predicate":"increases","statement":"In 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8c8c84dd-8809-57ec-9a64-b3673f4b5ced","mechanism_event_label":"In 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.","subject":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"object":{"id":"e8580014-4ce1-57fb-9057-d54e2f52ee9b","slug":"human-serum-vitamin-c","display_name":"Human serum vitamin C concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8c8c84dd-8809-57ec-9a64-b3673f4b5ced","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-vitamin-c-event","event_type":"observed_relationship","label":"In 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.","description":"In 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e8580014-4ce1-57fb-9057-d54e2f52ee9b","slug":"human-serum-vitamin-c","display_name":"Human serum vitamin C concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Purified hydroxytyrosol 45 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fourteen human volunteers with mild hyperlipidemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The study compared follow-up with baseline and did not resolve the mechanism or prove benefit from combining supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Fourteen human volunteers with mild hyperlipidemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28063380/ DOI: 10.1016/j.redox.2016.12.014","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Vitamins, minerals and clinical chemistry","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34841100-c5a3-5808-aa54-37b20cbad215","evidence_kind":"source_excerpt","locator":"Lines 99-108","start_line":99,"end_line":108,"excerpt":"## hydroxytyrosol-vitamin-c\nIn 14 volunteers with mild hyperlipidemia, 45 mg/day purified hydroxytyrosol doubled measured vitamin C at weeks 4 and 8 relative to baseline.\nModel/species: Fourteen human volunteers with mild hyperlipidemia\nTissue/system: Vitamins, minerals and clinical chemistry\nExposure: Purified hydroxytyrosol 45 mg/day\nRoute: Oral\nDuration: 8 weeks\nLimits: The study compared follow-up with baseline and did not resolve the mechanism or prove benefit from combining supplements.\nPrimary reference: Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28063380/ DOI: 10.1016/j.redox.2016.12.014\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Fourteen human volunteers with mild hyperlipidemia","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}