{"id":"472d7f8a-e152-5c33-bc04-1abb658cc63d","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-cyp27b1-transcript","predicate":"low_supply_changes_transcript_abundance","statement":"Magnesium deprivation decreased renal cyp27b1-mrna abundance in the 21-day rat experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"33add84f-cf14-5ebf-bc09-e7f6c2bc8da7","mechanism_event_label":"The kidney made less of the message for vitamin D activation.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"fccedced-8581-50c2-8a8f-021c77be9883","slug":"cyp27b1-mrna","display_name":"CYP27B1 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"33add84f-cf14-5ebf-bc09-e7f6c2bc8da7","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-cyp27b1-transcript-event","event_type":"biochemical_relationship","label":"The kidney made less of the message for vitamin D activation.","description":"Magnesium deprivation decreased renal cyp27b1-mrna abundance in the 21-day rat experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1d0238c-7529-5175-b5f9-71dc9bc61ed5","slug":"cyp27b1","display_name":"Vitamin D 1-alpha-hydroxylase / CYP27B1","entity_type_key":"protein"},"role":"encoded_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; 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no transporter flux or obligatory enzyme-bound Mg inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The kidney made less of the message for vitamin D activation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-matsuzaki2013] Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats (2013). https://pubmed.ncbi.nlm.nih.gov/23816829/ DOI: 10.1684/mrh.2013.0341","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Rat kidney","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [mg-matsuzaki2013] Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats (2013). https://pubmed.ncbi.nlm.nih.gov/23816829/ DOI: 10.1684/mrh.2013.0341","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}