{"id":"46c1cc48-07d6-5f87-afb0-3dc5e1250ec8","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-exercise-muscle-specificity","predicate":"has_endpoint_specific_effect","statement":"The related older-men study found no additive or adverse resveratrol effect on several exercise-induced mitochondrial/endurance measures, but blunting of reduced protein carbonylation and TNF-alpha mRNA.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7ddc04a9-d838-57d6-8953-06f1c9303b40","mechanism_event_label":"Different outcomes within an exercise program can move differently.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"47d2246b-fd6e-582d-924d-82e75b96ef1f","slug":"human-older-men-training-muscle-response","display_name":"Skeletal-muscle response to exercise/resveratrol in older men","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ddc04a9-d838-57d6-8953-06f1c9303b40","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-exercise-muscle-specificity-event","event_type":"observed_relationship","label":"Different outcomes within an exercise program can move differently.","description":"The related older-men study found no additive or adverse resveratrol effect on several exercise-induced mitochondrial/endurance measures, but blunting of reduced protein carbonylation and TNF-alpha mRNA.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"47d2246b-fd6e-582d-924d-82e75b96ef1f","slug":"human-older-men-training-muscle-response","display_name":"Skeletal-muscle response to exercise/resveratrol in older men","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight weeks, 250 mg/day; overlapping training investigation with additional nontraining arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not count related reports as independent replications or confuse muscle endpoints with the cardiovascular report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Different outcomes within an exercise program can move differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24514907/ · DOI 10.1113/jphysiol.2013.270256","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c1f27c0f-ffa5-5563-a4c1-2d1aecacc7e4","evidence_kind":"source_excerpt","locator":"Lines 486-492","start_line":486,"end_line":492,"excerpt":"## resveratrol-exercise-muscle-specificity\nDifferent outcomes within an exercise program can move differently.\nThe related older-men study found no additive or adverse resveratrol effect on several exercise-induced mitochondrial/endurance measures, but blunting of reduced protein carbonylation and TNF-alpha mRNA.\nModel: Eight weeks, 250 mg/day; overlapping training investigation with additional nontraining arms.\nLimitations: Do not count related reports as independent replications or confuse muscle endpoints with the cardiovascular report.\nEvidence access: Primary abstract\nExercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24514907/ · DOI 10.1113/jphysiol.2013.270256","model_system":"Eight weeks, 250 mg/day; overlapping training investigation with additional nontraining arms.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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