{"id":"46432ba9-437b-5e3c-809f-61809fdec964","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-benfotiamine-human-age-null","predicate":"does_not_significantly_reduce","statement":"The same trial found no significant reduction in plasma/urinary AGE markers or measured endothelial and inflammatory biomarkers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8f99f80c-c67a-549d-8173-ef5d2d4af591","mechanism_event_label":"The proposed vascular pathways did not show a clear biomarker response in these participants.","subject":{"id":"bbd53f1e-98b5-50b8-8de8-b414b34b35a2","slug":"benfotiamine","display_name":"Benfotiamine","entity_type_key":"small_molecule"},"object":{"id":"25000966-5e50-5b8b-bcf2-3f4a69f42568","slug":"circulating-urinary-age-markers","display_name":"Circulating and urinary glycation markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8f99f80c-c67a-549d-8173-ef5d2d4af591","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-benfotiamine-human-age-null-event","event_type":"observed_intervention","label":"The proposed vascular pathways did not show a clear biomarker response in these participants.","description":"The same trial found no significant reduction in plasma/urinary AGE markers or measured endothelial and inflammatory biomarkers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bbd53f1e-98b5-50b8-8de8-b414b34b35a2","slug":"benfotiamine","display_name":"Benfotiamine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"25000966-5e50-5b8b-bcf2-3f4a69f42568","slug":"circulating-urinary-age-markers","display_name":"Circulating and urinary glycation markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Same 82-person trial, biomarker report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Same 900 mg/day, 12-week benfotiamine trial as b1-alkhalaf2010; not an independent sample.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an independent cohort; systemic biomarkers do not directly measure retinal pathway flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The proposed vascular pathways did not show a clear biomarker response in these participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-alkhalaf2012] Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy (2012). https://pubmed.ncbi.nlm.nih.gov/22792314/ DOI: 10.1371/journal.pone.0040427","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma/urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9d30f81-1be5-5f85-8ac8-4af02b5e7b45","evidence_kind":"source_excerpt","locator":"Lines 1867-1877","start_line":1867,"end_line":1877,"excerpt":"### b1-benfotiamine-human-age-null\nThe same trial found no significant reduction in plasma/urinary AGE markers or measured endothelial and inflammatory biomarkers.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The proposed vascular pathways did not show a clear biomarker response in these participants.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma/urine\nexperimental_model: Same 82-person trial, biomarker report.\nlimitations: Not an independent cohort; systemic biomarkers do not directly measure retinal pathway flux.\nexposure: Same 900 mg/day, 12-week benfotiamine trial as b1-alkhalaf2010; not an independent sample.\n[b1-alkhalaf2012] Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy (2012). https://pubmed.ncbi.nlm.nih.gov/22792314/ DOI: 10.1371/journal.pone.0040427","model_system":"Same 82-person trial, biomarker report.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-alkhalaf2012] Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy (2012). https://pubmed.ncbi.nlm.nih.gov/22792314/ DOI: 10.1371/journal.pone.0040427","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}