{"id":"4619c7c7-f57f-5900-991d-2c3c0a07dd56","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-not-universal","predicate":"no_universal_age_decline","statement":"The 2025 study found circulating taurine increased or remained unchanged with age in three geographically distinct human cohorts, with longitudinal and cross-sectional analyses and supporting nonhuman datasets.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"274a1252-49d2-5a7a-a2e6-a1e653546845","mechanism_event_label":"Later data did not reproduce a consistent age-related decline.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"3e18e232-a230-54c2-a892-4b132e55ccee","slug":"human-aging-circulating-taurine","display_name":"Human circulating taurine across age","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"274a1252-49d2-5a7a-a2e6-a1e653546845","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-not-universal-event","event_type":"observed_relationship","label":"Later data did not reproduce a consistent age-related decline.","description":"The 2025 study found circulating taurine increased or remained unchanged with age in three geographically distinct human cohorts, with longitudinal and cross-sectional analyses and supporting nonhuman datasets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3e18e232-a230-54c2-a892-4b132e55ccee","slug":"human-aging-circulating-taurine","display_name":"Human circulating taurine across age","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cohorts plus nonhuman primates and mice; repeated and cross-sectional measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A biomarker challenge does not by itself refute every animal supplementation outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Later data did not reproduce a consistent age-related decline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Is taurine an aging biomarker? · 2025 · https://pubmed.ncbi.nlm.nih.gov/40472098/ · DOI 10.1126/science.adl2116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"74d62d56-69ed-5573-8984-4fe9b0f2b403","evidence_kind":"source_excerpt","locator":"Lines 577-583","start_line":577,"end_line":583,"excerpt":"## taurine-aging-not-universal\nLater data did not reproduce a consistent age-related decline.\nThe 2025 study found circulating taurine increased or remained unchanged with age in three geographically distinct human cohorts, with longitudinal and cross-sectional analyses and supporting nonhuman datasets.\nModel: Human cohorts plus nonhuman primates and mice; repeated and cross-sectional measurements.\nLimitations: A biomarker challenge does not by itself refute every animal supplementation outcome.\nEvidence access: Primary abstract\nIs taurine an aging biomarker? · 2025 · https://pubmed.ncbi.nlm.nih.gov/40472098/ · DOI 10.1126/science.adl2116","model_system":"Human cohorts plus nonhuman primates and mice; repeated and cross-sectional measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"349eb6bc-52fa-5e29-8338-2943bd8961fe","title":"Does circulating taurine consistently decline with age?","kind":"contradiction","status":"open","why":"The 2023 paper reported age-related decline and proposed taurine deficiency as an aging driver; independent 2025 human cohort analyses found stable or increased levels, and another male cohort found no age association. These oppose a universal circulating-taurine decline, rather than correcting a draft label.","resolution":"Unresolved across datasets. Preserve sampling design, population, diet, activity, renal handling and measurement context as candidate explanations. Blood concentration is not a universal tissue-deficiency threshold. These observational disagreements do not directly negate the separate mouse intervention results or establish human lifespan benefit.","created_at":"2026-09-19 05:09:30","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/349eb6bc-52fa-5e29-8338-2943bd8961fe","sides":[{"conflict_id":"349eb6bc-52fa-5e29-8338-2943bd8961fe","ordinal":0,"label":"Reported decline in 2023","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","start_line":569,"end_line":575,"quote":"## taurine-aging-decline\nThe original aging paper reported a fall in blood taurine.\nThe 2023 study reported lower circulating taurine with age in its human samples, alongside corresponding age comparisons in mice and monkeys.\nModel: Human age-group observations; separate animal datasets.\nLimitations: Association alone does not establish deficiency as a cause or specify a universal threshold.\nEvidence access: Primary abstract\nTaurine deficiency as a driver of aging. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37289866/ · DOI 10.1126/science.abn9257","source_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","source_title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","claim_ids":["74217d3f-6d8b-5e0f-9092-5ecc5d03fd65"]},{"conflict_id":"349eb6bc-52fa-5e29-8338-2943bd8961fe","ordinal":1,"label":"Stable or increasing concentrations in 2025 cohorts","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","start_line":577,"end_line":583,"quote":"## taurine-aging-not-universal\nLater data did not reproduce a consistent age-related decline.\nThe 2025 study found circulating taurine increased or remained unchanged with age in three geographically distinct human cohorts, with longitudinal and cross-sectional analyses and supporting nonhuman datasets.\nModel: Human cohorts plus nonhuman primates and mice; repeated and cross-sectional measurements.\nLimitations: A biomarker challenge does not by itself refute every animal supplementation outcome.\nEvidence access: Primary abstract\nIs taurine an aging biomarker? · 2025 · https://pubmed.ncbi.nlm.nih.gov/40472098/ · DOI 10.1126/science.adl2116","source_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","source_title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","claim_ids":["4619c7c7-f57f-5900-991d-2c3c0a07dd56"]},{"conflict_id":"349eb6bc-52fa-5e29-8338-2943bd8961fe","ordinal":2,"label":"No association in 137 men","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","start_line":585,"end_line":591,"quote":"## taurine-aging-men-null\nAnother human dataset did not support blood taurine as a simple aging signal.\nIn 137 physically active and inactive men aged 20–93, circulating taurine was not associated with age, muscle mass, strength, physical performance or mitochondrial function.\nModel: Human observational study of men spanning adult ages.\nLimitations: No randomized taurine intervention; findings do not establish equivalence in women or every tissue.\nEvidence access: Primary abstract\nExperimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/41061678/ · DOI 10.1111/acel.70191","source_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","source_title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","claim_ids":["24eaf05a-31f7-5518-bf75-f1375bd19658"]}]}],"corrections":[],"research":null}